Concurrent paclitaxel-containing regimens and thoracic radiation therapy for limited-disease small cell lung cancer

Research output: Contribution to journalArticle

Abstract

Therapy for limited-disease (LD) small cell lung cancer (SCLC) includes combined modality therapy using radiation (XRT) and systemic chemotherapy. Because such therapy is effective in treating the disease, LD SCLC is now considered potentially curable. Based on data from the Intergroup study, the current standard chemotherapy regimen is etoposide plus either cisplatin or carboplatin administered concomitantly with XRT given once or twice daily. Paclitaxel has demonstrated efficacy in the treatment of extensive-disease (ED) SCLC and in vitro data suggest that the agent has significant radiosensitizing potential. The Sarah Cannon Cancer Center, Nashville, TN, recently reported the results of two sequential phase II studies evaluating two paclitaxel doses in combination with cisplatin and etoposide for SCLC; patients with LD SCLC also received XRT. Patients with LD SCLC demonstrated a higher overall response rate to the higher-dose regimen; median survival was 17 months with the lower-dose regimen and more than 16 months with the higher-dose regimen. Three additional studies are under way to further evaluate the role of paclitaxel in combination with cisplatin, etoposide, and XRT therapy for the treatment of LD SCLC. Although the number of evaluable patients is limited and all studies are ongoing, preliminary results thus far appear encouraging.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalSeminars in Radiation Oncology
Volume9
Issue number2 SUPPL. 1
StatePublished - 1999

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Small Cell Lung Carcinoma
Paclitaxel
lungs
radiation therapy
Radiotherapy
Thorax
cancer
Etoposide
Cisplatin
therapy
dosage
chemotherapy
guns (ordnance)
Drug Therapy
Combined Modality Therapy
Carboplatin
Therapeutics
Radiation
Survival
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

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title = "Concurrent paclitaxel-containing regimens and thoracic radiation therapy for limited-disease small cell lung cancer",
abstract = "Therapy for limited-disease (LD) small cell lung cancer (SCLC) includes combined modality therapy using radiation (XRT) and systemic chemotherapy. Because such therapy is effective in treating the disease, LD SCLC is now considered potentially curable. Based on data from the Intergroup study, the current standard chemotherapy regimen is etoposide plus either cisplatin or carboplatin administered concomitantly with XRT given once or twice daily. Paclitaxel has demonstrated efficacy in the treatment of extensive-disease (ED) SCLC and in vitro data suggest that the agent has significant radiosensitizing potential. The Sarah Cannon Cancer Center, Nashville, TN, recently reported the results of two sequential phase II studies evaluating two paclitaxel doses in combination with cisplatin and etoposide for SCLC; patients with LD SCLC also received XRT. Patients with LD SCLC demonstrated a higher overall response rate to the higher-dose regimen; median survival was 17 months with the lower-dose regimen and more than 16 months with the higher-dose regimen. Three additional studies are under way to further evaluate the role of paclitaxel in combination with cisplatin, etoposide, and XRT therapy for the treatment of LD SCLC. Although the number of evaluable patients is limited and all studies are ongoing, preliminary results thus far appear encouraging.",
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AB - Therapy for limited-disease (LD) small cell lung cancer (SCLC) includes combined modality therapy using radiation (XRT) and systemic chemotherapy. Because such therapy is effective in treating the disease, LD SCLC is now considered potentially curable. Based on data from the Intergroup study, the current standard chemotherapy regimen is etoposide plus either cisplatin or carboplatin administered concomitantly with XRT given once or twice daily. Paclitaxel has demonstrated efficacy in the treatment of extensive-disease (ED) SCLC and in vitro data suggest that the agent has significant radiosensitizing potential. The Sarah Cannon Cancer Center, Nashville, TN, recently reported the results of two sequential phase II studies evaluating two paclitaxel doses in combination with cisplatin and etoposide for SCLC; patients with LD SCLC also received XRT. Patients with LD SCLC demonstrated a higher overall response rate to the higher-dose regimen; median survival was 17 months with the lower-dose regimen and more than 16 months with the higher-dose regimen. Three additional studies are under way to further evaluate the role of paclitaxel in combination with cisplatin, etoposide, and XRT therapy for the treatment of LD SCLC. Although the number of evaluable patients is limited and all studies are ongoing, preliminary results thus far appear encouraging.

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