Concurrent myeloid sarcoma, atypical teratoid/rhabdoid tumor, and hypereosinophilia in an infant with a germline SMARCB1 mutation

Jonathan L. Metts, Sunita I. Park, Bruno P. Soares, Cindy Fong, Jaclyn A. Biegel, Kelly C. Goldsmith

Research output: Contribution to journalArticle

Abstract

We report a 1-year-old female child presenting with hypereosinophilia who was found to have concurrent myeloid sarcoma and a central nervous system (CNS) atypical teratoid/rhabdoid tumor (AT/RT). She was later found to have a germline mutation in SMARCB1. Concurrent hematologic malignancy and CNS AT/RT have not previously been described in the context of a SMARCB1 loss-of-function germline mutation.

Original languageEnglish (US)
Article numbere26460
JournalPediatric Blood and Cancer
Volume64
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • SMARCB1
  • brain tumors
  • eosinophilia
  • myeloid sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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