TY - JOUR
T1 - Concurrent evaluation of p53, β-catenin, and α-fetoprotein expression in human hepatocellular carcinoma
AU - Torbenson, Michael
AU - Kannangai, Rajesh
AU - Abraham, Susan
AU - Sahin, Fikret
AU - Choti, Michael
AU - Wang, Jianzhou
PY - 2004/9
Y1 - 2004/9
N2 - Recent models suggest that hepatocellular carcinoma (HCC) develops through several independent pathways marked by key mutations in the β-catenin or p53 gene. An additional pathway potentially is marked by aberrant expression of a-fetoprotein (AFP). To see whether these potential markers are expressed independently, we immunostained sequential sections from 55 HCCs. Of the cases, 30 (55%) were positive for 1 or more proteins: AFP, 19 cases (35%); p53, 12 cases (22%); and β-catenin, 9 cases (16%). Seven tumors (13%) were positive for more than 1 protein, with 4 of 7 positive in the same area of tumor and 3 of 7 positive in different areas of the carcinomas. By statistical analysis, expression of the markers was independent of one another and of tumor size. Concurrent evaluation of p53, β-catenin, and AFP protein expression showed no associations, supporting models in which these proteins might serve as markers of independent pathways in the development of HCC.
AB - Recent models suggest that hepatocellular carcinoma (HCC) develops through several independent pathways marked by key mutations in the β-catenin or p53 gene. An additional pathway potentially is marked by aberrant expression of a-fetoprotein (AFP). To see whether these potential markers are expressed independently, we immunostained sequential sections from 55 HCCs. Of the cases, 30 (55%) were positive for 1 or more proteins: AFP, 19 cases (35%); p53, 12 cases (22%); and β-catenin, 9 cases (16%). Seven tumors (13%) were positive for more than 1 protein, with 4 of 7 positive in the same area of tumor and 3 of 7 positive in different areas of the carcinomas. By statistical analysis, expression of the markers was independent of one another and of tumor size. Concurrent evaluation of p53, β-catenin, and AFP protein expression showed no associations, supporting models in which these proteins might serve as markers of independent pathways in the development of HCC.
KW - Hepatocellular carcinoma
KW - P53
KW - α-Fetoprotein
KW - β-Catenin
UR - http://www.scopus.com/inward/record.url?scp=4344675090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4344675090&partnerID=8YFLogxK
U2 - 10.1309/YH0H3FKYM4RMU1JF
DO - 10.1309/YH0H3FKYM4RMU1JF
M3 - Article
C2 - 15362367
AN - SCOPUS:4344675090
SN - 0002-9173
VL - 122
SP - 377
EP - 382
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 3
ER -