Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer

Arlene A. Forastiere, Helmuth Goepfert, Moshe Maor, Thomas F. Pajak, Randal Weber, William Morrison, Bonnie Glisson, Andy Trotti, John A. Ridge, Clifford Chao, Glen Peters, Ding Jen Lee, Andrea Leaf, John Ensley, Jay Cooper

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown. METHODS: We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with concurrent administration of cisplatin, or radiotherapy alone. The primary end point was preservation of the larynx. RESULTS: A total of 547 patients were randomly assigned to one of the three study groups. The median follow-up period was 3.8 years. At two years, the proportion of patients who had an intact larynx after radiotherapy with concurrent cisplatin (88 percent) differed significantly from the proportions in the groups given induction chemotherapy followed by radiotherapy (75 percent, P=0.005) or radiotherapy alone (70 percent, P

Original languageEnglish (US)
Pages (from-to)2091-2098
Number of pages8
JournalNew England Journal of Medicine
Volume349
Issue number22
DOIs
StatePublished - Nov 27 2003

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Organ Preservation
Laryngeal Neoplasms
Radiotherapy
Drug Therapy
Cisplatin
Induction Chemotherapy
Larynx
Fluorouracil
Laryngectomy

ASJC Scopus subject areas

  • Medicine(all)

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Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer. / Forastiere, Arlene A.; Goepfert, Helmuth; Maor, Moshe; Pajak, Thomas F.; Weber, Randal; Morrison, William; Glisson, Bonnie; Trotti, Andy; Ridge, John A.; Chao, Clifford; Peters, Glen; Lee, Ding Jen; Leaf, Andrea; Ensley, John; Cooper, Jay.

In: New England Journal of Medicine, Vol. 349, No. 22, 27.11.2003, p. 2091-2098.

Research output: Contribution to journalArticle

Forastiere, AA, Goepfert, H, Maor, M, Pajak, TF, Weber, R, Morrison, W, Glisson, B, Trotti, A, Ridge, JA, Chao, C, Peters, G, Lee, DJ, Leaf, A, Ensley, J & Cooper, J 2003, 'Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer', New England Journal of Medicine, vol. 349, no. 22, pp. 2091-2098. https://doi.org/10.1056/NEJMoa031317
Forastiere, Arlene A. ; Goepfert, Helmuth ; Maor, Moshe ; Pajak, Thomas F. ; Weber, Randal ; Morrison, William ; Glisson, Bonnie ; Trotti, Andy ; Ridge, John A. ; Chao, Clifford ; Peters, Glen ; Lee, Ding Jen ; Leaf, Andrea ; Ensley, John ; Cooper, Jay. / Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer. In: New England Journal of Medicine. 2003 ; Vol. 349, No. 22. pp. 2091-2098.
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AU - Goepfert, Helmuth

AU - Maor, Moshe

AU - Pajak, Thomas F.

AU - Weber, Randal

AU - Morrison, William

AU - Glisson, Bonnie

AU - Trotti, Andy

AU - Ridge, John A.

AU - Chao, Clifford

AU - Peters, Glen

AU - Lee, Ding Jen

AU - Leaf, Andrea

AU - Ensley, John

AU - Cooper, Jay

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