Concurrent anemia and elevated C-reactive protein predicts HIV clinical treatment failure, including tuberculosis, after antiretroviral therapy initiation

Rupak Shivakoti, Wei Teng Yang, Nikhil Gupte, Sima Berendes, Alberto La Rosa, Sandra W. Cardoso, Noluthando Mwelase, Cecilia Kanyama, Sandy Pillay, Wadzanai Samaneka, Cynthia Riviere, Patcharaphan Sugandhavesa, Brento Santos, Selvamuthu Poongulali, Srikanth Tripathy, Robert C Bollinger, Judith S. Currier, Alice M. Tang, Richard David Semba, Parul S ChristianThomas B. Campbell, Amita Gupta

Research output: Contribution to journalArticle

Abstract

Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (HIV) treatment outcomes, yet their joint effect is not known. The objective of this study was to assess prevalence and risk factors of anemia in HIV infection and to determine whether anemia and elevated CRP jointly predict clinical failure post-ART. Methods: A case-cohort study (N = 470 [236 cases, 234 controls]) was nested within a multinational randomized trial of ART efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings [PEARLS]). Cases were incident World Health Organization stage 3, 4, or death by 96 weeks of ART treatment (clinical failure). Multivariable logistic regression was used to determine risk factors for pre-ART (baseline) anemia (females: hemoglobin

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalClinical Infectious Diseases
Volume61
Issue number1
DOIs
StatePublished - Jul 1 2015

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Treatment Failure
C-Reactive Protein
Anemia
Tuberculosis
HIV
Inflammation
Therapeutics
Virus Diseases
Hemoglobins
Cohort Studies
Logistic Models

Keywords

  • anemia
  • antiretroviral therapy
  • CRP
  • HIV
  • inflammation

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Concurrent anemia and elevated C-reactive protein predicts HIV clinical treatment failure, including tuberculosis, after antiretroviral therapy initiation. / Shivakoti, Rupak; Yang, Wei Teng; Gupte, Nikhil; Berendes, Sima; Rosa, Alberto La; Cardoso, Sandra W.; Mwelase, Noluthando; Kanyama, Cecilia; Pillay, Sandy; Samaneka, Wadzanai; Riviere, Cynthia; Sugandhavesa, Patcharaphan; Santos, Brento; Poongulali, Selvamuthu; Tripathy, Srikanth; Bollinger, Robert C; Currier, Judith S.; Tang, Alice M.; Semba, Richard David; Christian, Parul S; Campbell, Thomas B.; Gupta, Amita.

In: Clinical Infectious Diseases, Vol. 61, No. 1, 01.07.2015, p. 102-110.

Research output: Contribution to journalArticle

Shivakoti, R, Yang, WT, Gupte, N, Berendes, S, Rosa, AL, Cardoso, SW, Mwelase, N, Kanyama, C, Pillay, S, Samaneka, W, Riviere, C, Sugandhavesa, P, Santos, B, Poongulali, S, Tripathy, S, Bollinger, RC, Currier, JS, Tang, AM, Semba, RD, Christian, PS, Campbell, TB & Gupta, A 2015, 'Concurrent anemia and elevated C-reactive protein predicts HIV clinical treatment failure, including tuberculosis, after antiretroviral therapy initiation', Clinical Infectious Diseases, vol. 61, no. 1, pp. 102-110. https://doi.org/10.1093/cid/civ265
Shivakoti, Rupak ; Yang, Wei Teng ; Gupte, Nikhil ; Berendes, Sima ; Rosa, Alberto La ; Cardoso, Sandra W. ; Mwelase, Noluthando ; Kanyama, Cecilia ; Pillay, Sandy ; Samaneka, Wadzanai ; Riviere, Cynthia ; Sugandhavesa, Patcharaphan ; Santos, Brento ; Poongulali, Selvamuthu ; Tripathy, Srikanth ; Bollinger, Robert C ; Currier, Judith S. ; Tang, Alice M. ; Semba, Richard David ; Christian, Parul S ; Campbell, Thomas B. ; Gupta, Amita. / Concurrent anemia and elevated C-reactive protein predicts HIV clinical treatment failure, including tuberculosis, after antiretroviral therapy initiation. In: Clinical Infectious Diseases. 2015 ; Vol. 61, No. 1. pp. 102-110.
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