Concise review

Stem cells, myocardial regeneration, and methodological artifacts

Piero Anversa, Annarosa Leri, Marcello Rota, Toru Hosoda, Claudia Bearzi, Konrad Urbanek, Jan Kajstura, Roberto Bolli

Research output: Contribution to journalArticle

Abstract

This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. Although great enthusiasm was created by the possibility of reconstituting the damaged heart, the opponents of this new concept of cardiac biology have interpreted most of the findings supporting this possibility as the product of technical artifacts. This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)589-601
Number of pages13
JournalStem Cells
Volume25
Issue number3
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Artifacts
Regeneration
Stem Cells
Hematopoietic Stem Cells
Cardiac Myocytes
Homeostasis
Wounds and Injuries
Growth

Keywords

  • Bone marrow cell transdifferentiation
  • Chimerism
  • Confocal and light microscopy
  • Enhanced green fluorescent protein autofluorescence
  • Heart
  • Mitosis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Anversa, P., Leri, A., Rota, M., Hosoda, T., Bearzi, C., Urbanek, K., ... Bolli, R. (2007). Concise review: Stem cells, myocardial regeneration, and methodological artifacts. Stem Cells, 25(3), 589-601. https://doi.org/10.1634/stemcells.2006-0623

Concise review : Stem cells, myocardial regeneration, and methodological artifacts. / Anversa, Piero; Leri, Annarosa; Rota, Marcello; Hosoda, Toru; Bearzi, Claudia; Urbanek, Konrad; Kajstura, Jan; Bolli, Roberto.

In: Stem Cells, Vol. 25, No. 3, 03.2007, p. 589-601.

Research output: Contribution to journalArticle

Anversa, P, Leri, A, Rota, M, Hosoda, T, Bearzi, C, Urbanek, K, Kajstura, J & Bolli, R 2007, 'Concise review: Stem cells, myocardial regeneration, and methodological artifacts', Stem Cells, vol. 25, no. 3, pp. 589-601. https://doi.org/10.1634/stemcells.2006-0623
Anversa P, Leri A, Rota M, Hosoda T, Bearzi C, Urbanek K et al. Concise review: Stem cells, myocardial regeneration, and methodological artifacts. Stem Cells. 2007 Mar;25(3):589-601. https://doi.org/10.1634/stemcells.2006-0623
Anversa, Piero ; Leri, Annarosa ; Rota, Marcello ; Hosoda, Toru ; Bearzi, Claudia ; Urbanek, Konrad ; Kajstura, Jan ; Bolli, Roberto. / Concise review : Stem cells, myocardial regeneration, and methodological artifacts. In: Stem Cells. 2007 ; Vol. 25, No. 3. pp. 589-601.
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