Concise review: Stem cells, myocardial regeneration, and methodological artifacts

Piero Anversa, Annarosa Leri, Marcello Rota, Toru Hosoda, Claudia Bearzi, Konrad Urbanek, Jan Kajstura, Roberto Bolli

Research output: Contribution to journalReview article

Abstract

This review discusses the current controversy about the role that endogenous and exogenous progenitor cells have in cardiac homeostasis and myocardial regeneration following injury. Although great enthusiasm was created by the possibility of reconstituting the damaged heart, the opponents of this new concept of cardiac biology have interpreted most of the findings supporting this possibility as the product of technical artifacts. This article challenges this established, static view of cardiac growth and favors the notion that the mammalian heart has the inherent ability to replace its cardiomyocytes through the activation of a pool of resident primitive cells or the administration of hematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)589-601
Number of pages13
JournalStem Cells
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2007

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Keywords

  • Bone marrow cell transdifferentiation
  • Chimerism
  • Confocal and light microscopy
  • Enhanced green fluorescent protein autofluorescence
  • Heart
  • Mitosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Anversa, P., Leri, A., Rota, M., Hosoda, T., Bearzi, C., Urbanek, K., Kajstura, J., & Bolli, R. (2007). Concise review: Stem cells, myocardial regeneration, and methodological artifacts. Stem Cells, 25(3), 589-601. https://doi.org/10.1634/stemcells.2006-0623