Concise review: Stem cell-based approaches to red blood cell production for transfusion

Siddharth Shah, Xiaosong Huang, Linzhao Cheng

Research output: Contribution to journalArticle

Abstract

Blood transfusion is a common procedure in modern medicine, and it is practiced throughout the world; however, many countries report a less than sufficient blood supply. Even in developed countries where the supply is currently adequate, projected demographics predict an insufficient supply as early as 2050. The blood supply is also strained during occasional widespread disasters and crises. Transfusion of blood components such as red blood cells (RBCs), platelets, or neutrophils is increasingly used from the same blood unit for multiple purposes and to reduce alloimmune responses. Even for RBCs and platelets lacking nuclei and many antigenic cell-surface molecules, alloimmunity could occur, especially in patients with chronic transfusion requirements. Once alloimmunization occurs, such patients require RBCs from donors with a different blood group antigen combination, making it a challenge to find donors after every successive episode of alloimmunization. Alternative blood substitutes such as synthetic oxygen carriers have so far proven unsuccessful. In this review, we focus on current research and technologies that permit RBC production ex vivo from hematopoietic stem cells, pluripotent stem cells, and immortalized erythroid precursors.

Original languageEnglish (US)
Pages (from-to)346-355
Number of pages10
JournalStem cells translational medicine
Volume3
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Erythrocyte Transfusion
Stem Cells
Erythrocytes
Blood Platelets
Blood Component Transfusion
Blood Substitutes
Pluripotent Stem Cells
Modern 1601-history
Disasters
Blood Group Antigens
Hematopoietic Stem Cells
Blood Donors
Developed Countries
Blood Transfusion
Neutrophils
Demography
Tissue Donors
Oxygen
Technology
Research

Keywords

  • Erythropoiesis
  • Hematopoietic stem cells
  • Pluripotent stem cells
  • Red blood cell transfusion
  • Reticulocytes

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Concise review : Stem cell-based approaches to red blood cell production for transfusion. / Shah, Siddharth; Huang, Xiaosong; Cheng, Linzhao.

In: Stem cells translational medicine, Vol. 3, No. 3, 2014, p. 346-355.

Research output: Contribution to journalArticle

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