@article{be73fae131394558a17f159a2cdc942b,
title = "Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles",
abstract = "Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV-based therapeutics at the preclinical and clinical levels. This review outlines topic-specific action items that, if addressed, will enhance the development of bestpractice models for EV therapies.",
keywords = "Cellular therapy, Clinical translation, Clinical trials, Exosomes, Extracellular vesicles, Microvesicles, Stem cells, Therapeutics",
author = "Reiner, {Agnes T.} and Witwer, {Kenneth W.} and {Van Balkom}, {Bas W.M.} and {De Beer}, Joel and Chaya Brodie and Corteling, {Randolph L.} and Susanne Gabrielsson and Mario Gimona and Ibrahim, {Ahmed G.} and {De Kleijn}, Dominique and Lai, {Charles P.} and Tvall, {Jan Lo} and {Del Portillo}, {Hernando A.} and Reischl, {Ilona G.} and Milad Riazifar and Carlos Salomon and Hidetoshi Tahara and Toh, {Wei Seong} and Wauben, {Marca H.M.} and Yang, {Vicky K.} and Yijun Yang and Yeo, {Ronne Wee Yeh} and Hang Yin and Bernd Giebel and Eva Rohde and Lim, {Sai Kiang}",
note = "Funding Information: aBioSensor Technologies, AIT Austrian Institute of Technology, Vienna, Austria; Departments of bMolecular and Comparative Pathobiology and cNeurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; dDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands; eAnjarium Biosciences AG, Zollikon, Switzerland; fDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA; gFaculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel; hReNeuron Group, Pencoed, United Kingdom; iDepartment of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden; jSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria; kDepartment of Blood Group Serology and Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; lCapricor Therapeutics, Los Angeles, California, USA; mDept. of Vascular Surgery & Cardiology, Utrecht University, Utrecht, The Netherlands; nNUS Surgery & A-STAR, Singapore; oInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China; pKrefting Research Centre, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; qCodiak BioSciences, Woburn, Massachusetts, USA; rICREA at ISGlobal Barcelona Institute for Global Health, Ctr. Int. Health Res. (CRESIB), Hospital Cl{\'i}nic, University of Barcelona, Barcelona, Spain; sInstitut d{\textquoteright}Investigaci{\'o} Germans Trias i Pujol (IGTP), Badalona, Spain; tFederal Office for Safety in Health Care; uAustrian Agency for Health and Food Safety, Institute Surveillance, Vienna, Austria; vDepartment of Pharmaceutical Sciences; wSue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA; xCentre for Clinical Research, Royal Brisbane and Women{\textquoteright}s Hospital, The University of Queensland, Brisbane, Australia; yDepartment of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA; zDepartment of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan; aaFaculty of Dentistry, National University of Singapore, Singapore; bbDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; ccDepartment of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA; ddState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; eeInstitute of Medical Biology, A*STAR, Singapore; ffDepartment of Chemistry and Funding Information: We acknowledge the contributions of all participants of the ISEV-SOCRATES Therapeutics Workshop.We also thank Amanda Steele for assistance with manuscript preparation and editing. Publisher Copyright: {\textcopyright} 2017 The Authors.",
year = "2017",
month = aug,
doi = "10.1002/sctm.17-0055",
language = "English (US)",
volume = "6",
pages = "1730--1739",
journal = "Stem Cells Translational Medicine",
issn = "2157-6564",
publisher = "AlphaMed Press",
number = "8",
}