Concepts related to salt resistant estradiol receptors in rat uterine nuclei: Nuclear matrix

Evelyn R. Barrack, Edward F. Hawkins, Steven L. Allen, L. Louise Hicks, Donald S. Coffey

Research output: Contribution to journalArticle

Abstract

When 3H-estradiol (0.1 μg) is injected into immature female rats, virtually all of the label that is recovered with uterine nuclei can be solubilized by 0.6 M KCl. Salt resistant uterine nuclear estrogen binding sites do not become labeled within one hour after the injection of 3H-estradiol, but these sites do exist and can be revealed when isolated nuclei are subjected to an in vitro estradiol exchange assay. These saturable, high affinity salt resistant sites appear to be associated with the uterine nuclear matrix, a residual structure of the nucleus.

Original languageEnglish (US)
Pages (from-to)829-836
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume79
Issue number3
DOIs
StatePublished - Dec 7 1977

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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