Concentrations of methadone in breast milk and plasma in the immediate perinatal period

Lauren M Jansson, Robin E. Choo, Cheryl Harrow, Martha Velez, Jennifer R. Schroeder, Ross Lowe, Marilyn A. Huestis

Research output: Contribution to journalArticle

Abstract

This study evaluates concentrations of methadone in breast milk and plasma among a sample of methadone-maintained women in the immediate perinatal period. Twelve methadone-maintained, lactating women provided blood and breast milk specimens 1, 2, 3, and 4 days after delivery. Specimens were collected at the time of trough (just before methadone dose) and peak (3 hours after dosing) maternal methadone levels. Paired specimens of foremilk (prefeed) and hindmilk (postfeed) were obtained at each sampling time. Although there was a significant increase in methadone concentration in breast milk over time for the peak postfeed sampling time, t (22) = 2.40, P = .0255, methadone concentrations in breast milk were small, ranging from 21 to 314 ng/mL, and were unrelated to maternal methadone dose. Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose.

Original languageEnglish (US)
Pages (from-to)184-190
Number of pages7
JournalJournal of Human Lactation
Volume23
Issue number2
DOIs
StatePublished - May 2007

Fingerprint

Methadone
Human Milk
Mothers
Breast Feeding

Keywords

  • Breast milk
  • Breastfeeding
  • Lactation
  • Methadone

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Concentrations of methadone in breast milk and plasma in the immediate perinatal period. / Jansson, Lauren M; Choo, Robin E.; Harrow, Cheryl; Velez, Martha; Schroeder, Jennifer R.; Lowe, Ross; Huestis, Marilyn A.

In: Journal of Human Lactation, Vol. 23, No. 2, 05.2007, p. 184-190.

Research output: Contribution to journalArticle

Jansson, LM, Choo, RE, Harrow, C, Velez, M, Schroeder, JR, Lowe, R & Huestis, MA 2007, 'Concentrations of methadone in breast milk and plasma in the immediate perinatal period', Journal of Human Lactation, vol. 23, no. 2, pp. 184-190. https://doi.org/10.1177/0890334407300336
Jansson, Lauren M ; Choo, Robin E. ; Harrow, Cheryl ; Velez, Martha ; Schroeder, Jennifer R. ; Lowe, Ross ; Huestis, Marilyn A. / Concentrations of methadone in breast milk and plasma in the immediate perinatal period. In: Journal of Human Lactation. 2007 ; Vol. 23, No. 2. pp. 184-190.
@article{6002ce4cb5ba4e81b81d87a8ebf77090,
title = "Concentrations of methadone in breast milk and plasma in the immediate perinatal period",
abstract = "This study evaluates concentrations of methadone in breast milk and plasma among a sample of methadone-maintained women in the immediate perinatal period. Twelve methadone-maintained, lactating women provided blood and breast milk specimens 1, 2, 3, and 4 days after delivery. Specimens were collected at the time of trough (just before methadone dose) and peak (3 hours after dosing) maternal methadone levels. Paired specimens of foremilk (prefeed) and hindmilk (postfeed) were obtained at each sampling time. Although there was a significant increase in methadone concentration in breast milk over time for the peak postfeed sampling time, t (22) = 2.40, P = .0255, methadone concentrations in breast milk were small, ranging from 21 to 314 ng/mL, and were unrelated to maternal methadone dose. Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose.",
keywords = "Breast milk, Breastfeeding, Lactation, Methadone",
author = "Jansson, {Lauren M} and Choo, {Robin E.} and Cheryl Harrow and Martha Velez and Schroeder, {Jennifer R.} and Ross Lowe and Huestis, {Marilyn A.}",
year = "2007",
month = "5",
doi = "10.1177/0890334407300336",
language = "English (US)",
volume = "23",
pages = "184--190",
journal = "Journal of Human Lactation",
issn = "0890-3344",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - Concentrations of methadone in breast milk and plasma in the immediate perinatal period

AU - Jansson, Lauren M

AU - Choo, Robin E.

AU - Harrow, Cheryl

AU - Velez, Martha

AU - Schroeder, Jennifer R.

AU - Lowe, Ross

AU - Huestis, Marilyn A.

PY - 2007/5

Y1 - 2007/5

N2 - This study evaluates concentrations of methadone in breast milk and plasma among a sample of methadone-maintained women in the immediate perinatal period. Twelve methadone-maintained, lactating women provided blood and breast milk specimens 1, 2, 3, and 4 days after delivery. Specimens were collected at the time of trough (just before methadone dose) and peak (3 hours after dosing) maternal methadone levels. Paired specimens of foremilk (prefeed) and hindmilk (postfeed) were obtained at each sampling time. Although there was a significant increase in methadone concentration in breast milk over time for the peak postfeed sampling time, t (22) = 2.40, P = .0255, methadone concentrations in breast milk were small, ranging from 21 to 314 ng/mL, and were unrelated to maternal methadone dose. Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose.

AB - This study evaluates concentrations of methadone in breast milk and plasma among a sample of methadone-maintained women in the immediate perinatal period. Twelve methadone-maintained, lactating women provided blood and breast milk specimens 1, 2, 3, and 4 days after delivery. Specimens were collected at the time of trough (just before methadone dose) and peak (3 hours after dosing) maternal methadone levels. Paired specimens of foremilk (prefeed) and hindmilk (postfeed) were obtained at each sampling time. Although there was a significant increase in methadone concentration in breast milk over time for the peak postfeed sampling time, t (22) = 2.40, P = .0255, methadone concentrations in breast milk were small, ranging from 21 to 314 ng/mL, and were unrelated to maternal methadone dose. Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose.

KW - Breast milk

KW - Breastfeeding

KW - Lactation

KW - Methadone

UR - http://www.scopus.com/inward/record.url?scp=34247635516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247635516&partnerID=8YFLogxK

U2 - 10.1177/0890334407300336

DO - 10.1177/0890334407300336

M3 - Article

VL - 23

SP - 184

EP - 190

JO - Journal of Human Lactation

JF - Journal of Human Lactation

SN - 0890-3344

IS - 2

ER -