Concentrations of Homovanillic Acid and 5‐Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period

Faye S. Silverstein, Steven Donn, Karen Buchanan, Michael V. Johnston

Research output: Contribution to journalArticle

Abstract

To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5‐HIAA levels were similar in all these subjects. HVA/5‐HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.

Original languageEnglish (US)
Pages (from-to)1769-1772
Number of pages4
JournalJournal of Neurochemistry
Volume43
Issue number6
DOIs
StatePublished - Dec 1984
Externally publishedYes

Keywords

  • CCSF
  • Development
  • Dopamine
  • Neonatal

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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