TY - JOUR
T1 - Concentrations of Homovanillic Acid and 5‐Hydroxyindoleacetic Acid in Cerebrospinal Fluid from Human Infants in the Perinatal Period
AU - Silverstein, Faye S.
AU - Donn, Steven
AU - Buchanan, Karen
AU - Johnston, Michael V.
PY - 1984/12
Y1 - 1984/12
N2 - To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5‐HIAA levels were similar in all these subjects. HVA/5‐HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.
AB - To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5‐hydroxyindoleacetic acid (5‐HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1–6 months old were studied. HVA levels increased with maturity (p < 0.05; ANOVA), whereas, 5‐HIAA levels were similar in all these subjects. HVA/5‐HIAA ratios increased markedly from 1 ± 0.12 in the most premature neonates to 1.98 ± 0.17 in the older infants (p < 0.01; t test). There were no sex differences for these values.
KW - CCSF
KW - Development
KW - Dopamine
KW - Neonatal
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U2 - 10.1111/j.1471-4159.1984.tb06109.x
DO - 10.1111/j.1471-4159.1984.tb06109.x
M3 - Article
C2 - 6208340
AN - SCOPUS:0021744678
VL - 43
SP - 1769
EP - 1772
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
SN - 0022-3042
IS - 6
ER -