TY - JOUR
T1 - COMT genotype and cognitive function
T2 - An 8-year longitudinal study in white and black elders
AU - Fiocco, A. J.
AU - Lindquist, K.
AU - Ferrell, R.
AU - Li, R.
AU - Simonsick, E. M.
AU - Nalls, M.
AU - Harris, T. B.
AU - Yaffe, K.
PY - 2010/4
Y1 - 2010/4
N2 - Objective: Catechol-O-methyltransferase (COMT), an enzyme that catalyzes the degradation of dopamine, is necessary for cognitive function. Few studies have examined the prospective association between COMT (valmet) genotype and cognition in older adults. Methods: We assessed a biracial cohort of 2,858 elderly subjects without dementia who were followed for 8 years. The Modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST) were administered at baseline and years 3, 5, and 8. COMT by race, gender, and APOE status interactions were examined. Results: Stratified by race and adjusted for covariates, repeated-measures mixed-effects models showed no association between COMT genotype and baseline cognitive function in black or white subjects. In white subjects, COMT was associated with change in 3MS (Met/Met:-2.3 [0.60], Met/Val:-1.7 [0.40], and Val/Val:-1.2 [0.50]) and DSST (Met/Met:-5.60 [1.00], Met/Val:-4.80 [0.70], Val/Val:-4.00 [0.90]). In black subjects, COMT was associated with change in the DSST (Met/Met:-4.10 [2.1], Met/Val:-4.80 [0.90], Val/Val-2.60 [1.00]). Conclusion: These findings suggest that the Val allele has a protective impact on cognitive decline in late life.
AB - Objective: Catechol-O-methyltransferase (COMT), an enzyme that catalyzes the degradation of dopamine, is necessary for cognitive function. Few studies have examined the prospective association between COMT (valmet) genotype and cognition in older adults. Methods: We assessed a biracial cohort of 2,858 elderly subjects without dementia who were followed for 8 years. The Modified Mini-Mental State Examination (3MS) and Digit Symbol Substitution Test (DSST) were administered at baseline and years 3, 5, and 8. COMT by race, gender, and APOE status interactions were examined. Results: Stratified by race and adjusted for covariates, repeated-measures mixed-effects models showed no association between COMT genotype and baseline cognitive function in black or white subjects. In white subjects, COMT was associated with change in 3MS (Met/Met:-2.3 [0.60], Met/Val:-1.7 [0.40], and Val/Val:-1.2 [0.50]) and DSST (Met/Met:-5.60 [1.00], Met/Val:-4.80 [0.70], Val/Val:-4.00 [0.90]). In black subjects, COMT was associated with change in the DSST (Met/Met:-4.10 [2.1], Met/Val:-4.80 [0.90], Val/Val-2.60 [1.00]). Conclusion: These findings suggest that the Val allele has a protective impact on cognitive decline in late life.
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U2 - 10.1212/WNL.0b013e3181d9edba
DO - 10.1212/WNL.0b013e3181d9edba
M3 - Article
C2 - 20404311
AN - SCOPUS:77951492779
SN - 0028-3878
VL - 74
SP - 1296
EP - 1302
JO - Neurology
JF - Neurology
IS - 16
ER -