Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder

D. Behar, J. L. Rapoport, C. J. Berg, M. B. Denckla, L. Mann, C. Cox, P. Fedio, T. Zahn, M. G. Wolfman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age ±SD=13.7 ± 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.

    Original languageEnglish (US)
    Pages (from-to)363-369
    Number of pages7
    JournalAmerican Journal of Psychiatry
    Volume141
    Issue number3
    DOIs
    StatePublished - Jan 1 1984

    ASJC Scopus subject areas

    • Psychiatry and Mental health

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