Computerized image analysis of nuclear shape as a prognostic factor for prostatic cancer

D. A. Diamond, S. J. Berry, Christopher B Umbricht, H. J. Jewett, D. S. Coffey

Research output: Contribution to journalArticle

Abstract

Computer assisted image analysis was used to determine quantitative and reproducible nuclear morphology of 17 totally excised pathological specimens from stage B-2 prostatic cancer in an attempt to correlate histopathological analysis with clinical prognosis for the individual patient. We describe a nuclear roundness factor that correlates with the clinical outcome of the individual patient. This nuclear shape factor appears to identify prostatic tumors with a high metastatic potential from tumors that are less aggressive. Quantitative nuclear image analysis, its accuracy, and reproducibility are described and discussed. This technique may provide the pathologist with a valuable tool for analyzing prostatic cancer cells in a quantitative manner, thereby contributing precise information to the urologist relevant to the prognosis of the individual patient.

Original languageEnglish (US)
Pages (from-to)321-332
Number of pages12
JournalProstate
Volume3
Issue number4
DOIs
StatePublished - 1982

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Prostatic Neoplasms
Computer-Assisted Image Processing
Neoplasms
Urologists
Pathologists

ASJC Scopus subject areas

  • Urology

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Computerized image analysis of nuclear shape as a prognostic factor for prostatic cancer. / Diamond, D. A.; Berry, S. J.; Umbricht, Christopher B; Jewett, H. J.; Coffey, D. S.

In: Prostate, Vol. 3, No. 4, 1982, p. 321-332.

Research output: Contribution to journalArticle

Diamond, D. A. ; Berry, S. J. ; Umbricht, Christopher B ; Jewett, H. J. ; Coffey, D. S. / Computerized image analysis of nuclear shape as a prognostic factor for prostatic cancer. In: Prostate. 1982 ; Vol. 3, No. 4. pp. 321-332.
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