Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

Jose M. Ferrero, Vicente Torres, Javier Saiz, Jose M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages1840-1841
Number of pages2
Volume5
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

Other

OtherProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)
CityAmsterdam, Neth
Period10/31/9611/3/96

Fingerprint

Adenosinetriphosphate
Potassium
Adenosine Triphosphate
Computer simulation
Chemical activation
Nucleotides
Tissue
Mathematical models

ASJC Scopus subject areas

  • Bioengineering

Cite this

Ferrero, J. M., Torres, V., Saiz, J., Ferrero, J. M., & Thakor, N. V. (1996). Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 5, pp. 1840-1841). IEEE.

Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. / Ferrero, Jose M.; Torres, Vicente; Saiz, Javier; Ferrero, Jose M.; Thakor, Nitish V.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5 IEEE, 1996. p. 1840-1841.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ferrero, JM, Torres, V, Saiz, J, Ferrero, JM & Thakor, NV 1996, Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 5, IEEE, pp. 1840-1841, Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5), Amsterdam, Neth, 10/31/96.
Ferrero JM, Torres V, Saiz J, Ferrero JM, Thakor NV. Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5. IEEE. 1996. p. 1840-1841
Ferrero, Jose M. ; Torres, Vicente ; Saiz, Javier ; Ferrero, Jose M. ; Thakor, Nitish V. / Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 5 IEEE, 1996. pp. 1840-1841
@inproceedings{a136eae0d2d64b25a6fb90a467829b3b,
title = "Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current",
abstract = "A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42{\%} to 2.20{\%} in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.",
author = "Ferrero, {Jose M.} and Vicente Torres and Javier Saiz and Ferrero, {Jose M.} and Thakor, {Nitish V}",
year = "1996",
language = "English (US)",
volume = "5",
pages = "1840--1841",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",

}

TY - GEN

T1 - Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

AU - Ferrero, Jose M.

AU - Torres, Vicente

AU - Saiz, Javier

AU - Ferrero, Jose M.

AU - Thakor, Nitish V

PY - 1996

Y1 - 1996

N2 - A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

AB - A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=0030312919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030312919&partnerID=8YFLogxK

M3 - Conference contribution

VL - 5

SP - 1840

EP - 1841

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

PB - IEEE

ER -