Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

Jose M. Ferrero; Vicente Torres; Javier Saiz; Jose M. Ferrero; Nitish V. Thakor

Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

Jose M. Ferrero, Vicente Torres, Javier Saiz, Jose M. Ferrero, Nitish V. Thakor

Research output: Contribution to journal › Conference article › peer-review

Abstract

A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K⁺ current (I_K(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of I_K(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that I_K(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, I_K(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

Original language	English (US)
Pages (from-to)	1840-1841
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	5
State	Published - 1996
Externally published	Yes
Event	Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth Duration: Oct 31 1996 → Nov 3 1996

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current. / Ferrero, Jose M.; Torres, Vicente; Saiz, Javier et al.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 5, 1996, p. 1840-1841.

Research output: Contribution to journal › Conference article › peer-review

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title = "Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current",

abstract = "A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.",

author = "Ferrero, {Jose M.} and Vicente Torres and Javier Saiz and Ferrero, {Jose M.} and Thakor, {Nitish V.}",

year = "1996",

language = "English (US)",

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issn = "1557-170X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) ; Conference date: 31-10-1996 Through 03-11-1996",

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TY - JOUR

T1 - Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

AU - Ferrero, Jose M.

AU - Torres, Vicente

AU - Saiz, Javier

AU - Ferrero, Jose M.

AU - Thakor, Nitish V.

PY - 1996

Y1 - 1996

N2 - A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

AB - A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

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JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

T2 - Proceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5)

Y2 - 31 October 1996 through 3 November 1996

ER -

Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

Abstract

ASJC Scopus subject areas

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