Computer simulation of action potential duration inhomogeneities in cardiac hypoxia. Role of the ATP-sensitive potassium current

Jose M. Ferrero, Vicente Torres, Javier Saiz, Jose M. Ferrero, Nitish V. Thakor

Research output: Contribution to journalConference article

Abstract

A mathematical model of the ventricular action potential has been used to study the contribution of the ATP-sensitive K+ current (IK(ATP)) to the spatial differences in action potential duration (APD) observed in cardiac hypoxia. A model of IK(ATP) has been formulated and introduced into the Luo-Rudy model of the ventricular action potential. Hypoxia was simulated in a one-dimensional linear model of the cardiac tissue. The sensitivity of K(ATP) channels to intracellular nucleotide levels was randomized, simulating the natural dispersion of this parameter. The results show that IK(ATP) activation significantly reduces APD and increases its spatial dispersion. The mean value of APD obtained under normoxic conditions was 154.5 ms, decreasing to 85.5 ms when hypoxia was simulated. The spatial APD coefficient of variance increases from 0.42% to 2.20% in said situations. Thus, IK(ATP) activation can cause spatial dispersion of APD in cardiac hypoxia.

Original languageEnglish (US)
Pages (from-to)1840-1841
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume5
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 5) - Amsterdam, Neth
Duration: Oct 31 1996Nov 3 1996

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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