Computer ranking of the sequence of appearance of 100 features of the brain and related structures in staged human embryos during the first 5 weeks of development

R. O'Rahilly, F. Muller, G. M. Hutchins, G. W. Moore

    Research output: Contribution to journalArticle

    Abstract

    The sequence of events in the development of the brain in staged human embryos was investigated in much greater detail than in previous studies by listing 100 features in 165 embryos of the first 5 weeks. Using a computerized bubble-sort algorithm, individual embryos were ranked in ascending order of the features present. This procedure made feasible an appreciation of the slight variation found in the developmental features. The vast majority of features appeared during either one or two stages (about 2 or 3 days). In general, the soundness of the Carnegie system of embryonic staging was amply confirmed. The rhombencephalon was found to show increasing complexity around stage 13, and the postoptic portion of the diencephalon underwent considerable differentiation by stage 15. The need for similar investigations of other systems of the body is emphasized, and the importance of such studies in assessing the timing of congenital malformations and in clarifying syndromic clusters is suggested.

    Original languageEnglish (US)
    Pages (from-to)243-257
    Number of pages15
    JournalAmerican Journal of Anatomy
    Volume171
    Issue number3
    StatePublished - 1984

    ASJC Scopus subject areas

    • Anatomy

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