Computer-Assisted Analysis of Regulation of the Glycerol-3-Phosphate Metabolism in Genomes of Proteobacteria

L. V. Danilova, M. S. Gelfand, V. A. Lyubetsky, O. N. Laikova

Research output: Contribution to journalArticlepeer-review

Abstract

Comparative computer-assisted analysis was used to study putative G1pR regulons responsible for metabolism of glycerol and glycerol-3-phosphate in genomes of α-, β-, and γ-proteobacteria. New palindromic G1pR-binding signals were identified in γ-proteobacteria, consensus sequences being TGTTCGATAACGAACA for Enterobacteriaceae, wTTTTCGTATACGAAAAw for Pseudomonadaceae, and AATGCTCGATCGAGCATT for Vibrionaceae. The signals in α- and β-proteobacteria were also identified: they contained 3-4 direct TTTCGTT repeats separated by 3-4 nucleotide pairs.

Original languageEnglish (US)
Pages (from-to)716-722
Number of pages7
JournalMolecular Biology
Volume37
Issue number5
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Computer-assisted analysis
  • G1pR
  • Operon structure
  • Tandem repeats
  • α-proteobacteria
  • β-proteobacteria
  • γ-proteobacteria

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology

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