Computer-aided morphometric data collection, mapping, and analysis for neuropathologists

Donald G. Lloyd, Harry L. Loats, Donald L. Price, Linda C. Cork

Research output: Contribution to journalArticlepeer-review


Neurologic diseases are frequently characterized by morphologic changes in neuronal tissue. Neuropathologists evaluate such changes by microscopic examination of brain and other tissues. This paper provides an overview of a microcomputer-based image acquisition and analysis system interfaced to an automated microscope directed at aiding neuropathologists in evaluating neuropathologic alterations. Information is provided on general system architecture and function. Details are provided on measurement techniques, key morphologic parameter calculations, data display, and analysis.

Original languageEnglish (US)
Pages (from-to)3390-3397
Number of pages8
JournalApplied Optics
Issue number16
StatePublished - Aug 15 1987

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering


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