Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: A prospective comparison

P. O. Alderson, D. F. Adams, B. J. McNeil, R. Sanders, S. S. Siegelman, H. J. Finberg, S. J. Hessel, H. L. Abrams

Research output: Contribution to journalArticle

Abstract

A prospective evaluation of computed tomography (CT), ultrasonography (US), and Tc-99m sulfur colloid scintigraphy of the liver was performed in 189 patients who had either colon (n = 129) or breast (n = 60) carcinoma. Imaging was performed with fourth-generation CT scanners, gray-scale or phased array ultrasound scanners, and 37-tube gamma cameras. Studies were evaluated independently and receiver operating characteristic (ROC) curves were constructed. In addition, a standard 2 x 2 matrix analysis was performed. In patients who had all three examinations (n = 122), the matrix analysis showed that CT had a slightly higher sensitivity (0.93) than scintigraphy (0.86) or US (0.82); specificities were 0.88, 0.83, and 0.85, respectively. These differences were not statistically significant. However, ROC curves showed that CT had the highest true-positive ratio at every false-positive ratio, and that US had the lowest. The performance of CT did not differ significantly from that of scintigraphy, but was better than that of US (p < .05), especially in patients with breast carcinoma. Overall, CT provided the most accurate means for detecting liver metastases from both primary lesions.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalUnknown Journal
Volume149
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Alderson, P. O., Adams, D. F., McNeil, B. J., Sanders, R., Siegelman, S. S., Finberg, H. J., Hessel, S. J., & Abrams, H. L. (1983). Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: A prospective comparison. Unknown Journal, 149(1), 225-230. https://doi.org/10.1148/radiology.149.1.6611929