TY - JOUR
T1 - Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma
T2 - A prospective comparison
AU - Alderson, P. O.
AU - Adams, D. F.
AU - McNeil, B. J.
AU - Sanders, R.
AU - Siegelman, S. S.
AU - Finberg, H. J.
AU - Hessel, S. J.
AU - Abrams, H. L.
PY - 1983
Y1 - 1983
N2 - A prospective evaluation of computed tomography (CT), ultrasonography (US), and Tc-99m sulfur colloid scintigraphy of the liver was performed in 189 patients who had either colon (n = 129) or breast (n = 60) carcinoma. Imaging was performed with fourth-generation CT scanners, gray-scale or phased array ultrasound scanners, and 37-tube gamma cameras. Studies were evaluated independently and receiver operating characteristic (ROC) curves were constructed. In addition, a standard 2 x 2 matrix analysis was performed. In patients who had all three examinations (n = 122), the matrix analysis showed that CT had a slightly higher sensitivity (0.93) than scintigraphy (0.86) or US (0.82); specificities were 0.88, 0.83, and 0.85, respectively. These differences were not statistically significant. However, ROC curves showed that CT had the highest true-positive ratio at every false-positive ratio, and that US had the lowest. The performance of CT did not differ significantly from that of scintigraphy, but was better than that of US (p < .05), especially in patients with breast carcinoma. Overall, CT provided the most accurate means for detecting liver metastases from both primary lesions.
AB - A prospective evaluation of computed tomography (CT), ultrasonography (US), and Tc-99m sulfur colloid scintigraphy of the liver was performed in 189 patients who had either colon (n = 129) or breast (n = 60) carcinoma. Imaging was performed with fourth-generation CT scanners, gray-scale or phased array ultrasound scanners, and 37-tube gamma cameras. Studies were evaluated independently and receiver operating characteristic (ROC) curves were constructed. In addition, a standard 2 x 2 matrix analysis was performed. In patients who had all three examinations (n = 122), the matrix analysis showed that CT had a slightly higher sensitivity (0.93) than scintigraphy (0.86) or US (0.82); specificities were 0.88, 0.83, and 0.85, respectively. These differences were not statistically significant. However, ROC curves showed that CT had the highest true-positive ratio at every false-positive ratio, and that US had the lowest. The performance of CT did not differ significantly from that of scintigraphy, but was better than that of US (p < .05), especially in patients with breast carcinoma. Overall, CT provided the most accurate means for detecting liver metastases from both primary lesions.
UR - http://www.scopus.com/inward/record.url?scp=0020529073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020529073&partnerID=8YFLogxK
U2 - 10.1148/radiology.149.1.6611929
DO - 10.1148/radiology.149.1.6611929
M3 - Article
C2 - 6611929
AN - SCOPUS:0020529073
SN - 0309-1708
VL - 149
SP - 225
EP - 230
JO - Unknown Journal
JF - Unknown Journal
IS - 1
ER -