TY - JOUR
T1 - Computed tomography of hepatic and splenic fungal abscesses in leukemic children
AU - Bartley, Douglas L.
AU - Hughes, Walter T.
AU - Parvey, Louis S.
AU - Parham, David
PY - 1982
Y1 - 1982
N2 - Six hundred fifty-eight abdominal computed tomography scans of 275 children with cancer were retrospectively studied for evidence of multiple hepatic or splenic "abscess-like" lesions. Seven patients, all with subsequently confirmed fungal disease, were found to have such lesions. In addition to acute leukemia, all patients had prolonged fever not responsive to antibiotics, had neutropenia (<500 neutrophils per mm3) and had received anticancer chemotherapy for up to 4 weeks before the positive computed tomography scans.We conclude that the presence of multiple well-circumscribed hepatic or splenic lesions on the abdominal computed tomography scan of a febrile, neutropenic, immunosuppressed patient not responding to antibiotics and with no other source of infection is strong evidence for systemic fungal infection. However, the absence of such lesions may not exclude the diagnosis of systemic mycosis.
AB - Six hundred fifty-eight abdominal computed tomography scans of 275 children with cancer were retrospectively studied for evidence of multiple hepatic or splenic "abscess-like" lesions. Seven patients, all with subsequently confirmed fungal disease, were found to have such lesions. In addition to acute leukemia, all patients had prolonged fever not responsive to antibiotics, had neutropenia (<500 neutrophils per mm3) and had received anticancer chemotherapy for up to 4 weeks before the positive computed tomography scans.We conclude that the presence of multiple well-circumscribed hepatic or splenic lesions on the abdominal computed tomography scan of a febrile, neutropenic, immunosuppressed patient not responding to antibiotics and with no other source of infection is strong evidence for systemic fungal infection. However, the absence of such lesions may not exclude the diagnosis of systemic mycosis.
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U2 - 10.1097/00006454-198209000-00007
DO - 10.1097/00006454-198209000-00007
M3 - Article
C2 - 6961378
AN - SCOPUS:0020331973
SN - 0891-3668
VL - 1
SP - 317
EP - 321
JO - Pediatric Infectious Disease
JF - Pediatric Infectious Disease
IS - 5
ER -