Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve

Michelle C. Williams, Saeed Mirsadraee, Marc R. Dweck, Nicholas W. Weir, Alison Fletcher, Christophe Lucatelli, Tom MacGillivray, Saroj K. Golay, Nicholas L. Cruden, Peter A. Henriksen, Neal Uren, Graham McKillop, Joao Lima, John H. Reid, Edwin J R van Beek, Dilip Patel, David E. Newby

Research output: Contribution to journalArticle

Abstract

Objectives: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR). Methods: 51 patients (63 (61–65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by “snapshot” adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR 15O-water PET MBF. CTCA and CTP can accurately identify obstructive CAD. Key Points: •CT myocardial perfusion can aid the assessment of suspected coronary artery disease. • CT attenuation density from “snapshot” imaging is a marker of myocardial perfusion. • CT myocardial attenuation density correlates with15O-water PET myocardial blood flow. • CT attenuation density is lower in obstructive territories defined by invasive angiography. • Diagnostic accuracy of CTCA+CTP is comparable to invasive angiography + fractional flow reserve.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalEuropean Radiology
DOIs
StateAccepted/In press - Jun 22 2016

Fingerprint

Coronary Angiography
Positron-Emission Tomography
Perfusion
Tomography
Water
Coronary Artery Disease
Coronary Stenosis
Angiography
Adenosine
Computed Tomography Angiography

Keywords

  • Angina
  • Angiography
  • Imaging
  • Ischaemia
  • Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Williams, M. C., Mirsadraee, S., Dweck, M. R., Weir, N. W., Fletcher, A., Lucatelli, C., ... Newby, D. E. (Accepted/In press). Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve. European Radiology, 1-11. https://doi.org/10.1007/s00330-016-4404-5

Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve. / Williams, Michelle C.; Mirsadraee, Saeed; Dweck, Marc R.; Weir, Nicholas W.; Fletcher, Alison; Lucatelli, Christophe; MacGillivray, Tom; Golay, Saroj K.; Cruden, Nicholas L.; Henriksen, Peter A.; Uren, Neal; McKillop, Graham; Lima, Joao; Reid, John H.; van Beek, Edwin J R; Patel, Dilip; Newby, David E.

In: European Radiology, 22.06.2016, p. 1-11.

Research output: Contribution to journalArticle

Williams, MC, Mirsadraee, S, Dweck, MR, Weir, NW, Fletcher, A, Lucatelli, C, MacGillivray, T, Golay, SK, Cruden, NL, Henriksen, PA, Uren, N, McKillop, G, Lima, J, Reid, JH, van Beek, EJR, Patel, D & Newby, DE 2016, 'Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve', European Radiology, pp. 1-11. https://doi.org/10.1007/s00330-016-4404-5
Williams, Michelle C. ; Mirsadraee, Saeed ; Dweck, Marc R. ; Weir, Nicholas W. ; Fletcher, Alison ; Lucatelli, Christophe ; MacGillivray, Tom ; Golay, Saroj K. ; Cruden, Nicholas L. ; Henriksen, Peter A. ; Uren, Neal ; McKillop, Graham ; Lima, Joao ; Reid, John H. ; van Beek, Edwin J R ; Patel, Dilip ; Newby, David E. / Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve. In: European Radiology. 2016 ; pp. 1-11.
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AU - Lucatelli, Christophe

AU - MacGillivray, Tom

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AU - Uren, Neal

AU - McKillop, Graham

AU - Lima, Joao

AU - Reid, John H.

AU - van Beek, Edwin J R

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