Computed tomography evidence of psoas muscle atrophy without concomitant tendon wasting in early sepsis

Carrie A. Kubiak, Kavitha Ranganathan, Niki Matusko, Jon A. Jacobson, Stewart C. Wang, Pauline K. Park, Benjamin L. Levi

Research output: Contribution to journalArticle

Abstract

Background: Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients. Materials and methods: The volume and fat content of bilateral psoas muscles and tendons were measured on abdominal computed tomography scans of 25 ICU septic and 25 control trauma patients admitted to the University of Michigan between 2011 and 2012. Univariate and multivariate analyses were performed to determine the relationship between psoas muscle and tendon morphometric data, and the association with clinical variables such as smoking and comorbidities. Results: Average psoas muscle volume was 12.21 ± 5.6 cm3 for control patients and 9.318 ± 3.3 cm3 in septic patients (P = 0.0023). The average psoas muscle/fat ratio for septic patients was 0.0288 ± 0.071 cm3, compared with 0.0107 ± 0.008 cm3 in the control group (P = 0.075). Average tendon volume in the septic population (0.508 ± 0.191 cm3) was not different than the control cohort (0.493 ± 0.182 cm3) (P = 0.692). Conclusions: Our results demonstrate significantly smaller psoas muscle volume in septic patients than in age-, gender-, and BMI-matched trauma patients but no demonstrable change in tendon morphology between patient groups. These findings begin to define the boundaries of clinical application within the field of morphomics.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalJournal of Surgical Research
Volume234
DOIs
StatePublished - Feb 1 2019
Externally publishedYes

Fingerprint

Psoas Muscles
Muscular Atrophy
Tendons
Sepsis
Tomography
Fats
Sarcopenia
Wounds and Injuries
Critical Illness
Comorbidity
Rehabilitation
Multivariate Analysis

Keywords

  • ICU-acquired weakness
  • Morphomics
  • Sarcopenia
  • Sepsis
  • Tendon

ASJC Scopus subject areas

  • Surgery

Cite this

Computed tomography evidence of psoas muscle atrophy without concomitant tendon wasting in early sepsis. / Kubiak, Carrie A.; Ranganathan, Kavitha; Matusko, Niki; Jacobson, Jon A.; Wang, Stewart C.; Park, Pauline K.; Levi, Benjamin L.

In: Journal of Surgical Research, Vol. 234, 01.02.2019, p. 210-216.

Research output: Contribution to journalArticle

Kubiak, Carrie A. ; Ranganathan, Kavitha ; Matusko, Niki ; Jacobson, Jon A. ; Wang, Stewart C. ; Park, Pauline K. ; Levi, Benjamin L. / Computed tomography evidence of psoas muscle atrophy without concomitant tendon wasting in early sepsis. In: Journal of Surgical Research. 2019 ; Vol. 234. pp. 210-216.
@article{285cc7e1623c4b70bdf423d8e8f4893b,
title = "Computed tomography evidence of psoas muscle atrophy without concomitant tendon wasting in early sepsis",
abstract = "Background: Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients. Materials and methods: The volume and fat content of bilateral psoas muscles and tendons were measured on abdominal computed tomography scans of 25 ICU septic and 25 control trauma patients admitted to the University of Michigan between 2011 and 2012. Univariate and multivariate analyses were performed to determine the relationship between psoas muscle and tendon morphometric data, and the association with clinical variables such as smoking and comorbidities. Results: Average psoas muscle volume was 12.21 ± 5.6 cm3 for control patients and 9.318 ± 3.3 cm3 in septic patients (P = 0.0023). The average psoas muscle/fat ratio for septic patients was 0.0288 ± 0.071 cm3, compared with 0.0107 ± 0.008 cm3 in the control group (P = 0.075). Average tendon volume in the septic population (0.508 ± 0.191 cm3) was not different than the control cohort (0.493 ± 0.182 cm3) (P = 0.692). Conclusions: Our results demonstrate significantly smaller psoas muscle volume in septic patients than in age-, gender-, and BMI-matched trauma patients but no demonstrable change in tendon morphology between patient groups. These findings begin to define the boundaries of clinical application within the field of morphomics.",
keywords = "ICU-acquired weakness, Morphomics, Sarcopenia, Sepsis, Tendon",
author = "Kubiak, {Carrie A.} and Kavitha Ranganathan and Niki Matusko and Jacobson, {Jon A.} and Wang, {Stewart C.} and Park, {Pauline K.} and Levi, {Benjamin L.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.jss.2018.09.010",
language = "English (US)",
volume = "234",
pages = "210--216",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Computed tomography evidence of psoas muscle atrophy without concomitant tendon wasting in early sepsis

AU - Kubiak, Carrie A.

AU - Ranganathan, Kavitha

AU - Matusko, Niki

AU - Jacobson, Jon A.

AU - Wang, Stewart C.

AU - Park, Pauline K.

AU - Levi, Benjamin L.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background: Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients. Materials and methods: The volume and fat content of bilateral psoas muscles and tendons were measured on abdominal computed tomography scans of 25 ICU septic and 25 control trauma patients admitted to the University of Michigan between 2011 and 2012. Univariate and multivariate analyses were performed to determine the relationship between psoas muscle and tendon morphometric data, and the association with clinical variables such as smoking and comorbidities. Results: Average psoas muscle volume was 12.21 ± 5.6 cm3 for control patients and 9.318 ± 3.3 cm3 in septic patients (P = 0.0023). The average psoas muscle/fat ratio for septic patients was 0.0288 ± 0.071 cm3, compared with 0.0107 ± 0.008 cm3 in the control group (P = 0.075). Average tendon volume in the septic population (0.508 ± 0.191 cm3) was not different than the control cohort (0.493 ± 0.182 cm3) (P = 0.692). Conclusions: Our results demonstrate significantly smaller psoas muscle volume in septic patients than in age-, gender-, and BMI-matched trauma patients but no demonstrable change in tendon morphology between patient groups. These findings begin to define the boundaries of clinical application within the field of morphomics.

AB - Background: Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant muscle and tendon wasting in sepsis patients. The results of this study may help to implement different rehabilitation modalities for critically ill patients. Materials and methods: The volume and fat content of bilateral psoas muscles and tendons were measured on abdominal computed tomography scans of 25 ICU septic and 25 control trauma patients admitted to the University of Michigan between 2011 and 2012. Univariate and multivariate analyses were performed to determine the relationship between psoas muscle and tendon morphometric data, and the association with clinical variables such as smoking and comorbidities. Results: Average psoas muscle volume was 12.21 ± 5.6 cm3 for control patients and 9.318 ± 3.3 cm3 in septic patients (P = 0.0023). The average psoas muscle/fat ratio for septic patients was 0.0288 ± 0.071 cm3, compared with 0.0107 ± 0.008 cm3 in the control group (P = 0.075). Average tendon volume in the septic population (0.508 ± 0.191 cm3) was not different than the control cohort (0.493 ± 0.182 cm3) (P = 0.692). Conclusions: Our results demonstrate significantly smaller psoas muscle volume in septic patients than in age-, gender-, and BMI-matched trauma patients but no demonstrable change in tendon morphology between patient groups. These findings begin to define the boundaries of clinical application within the field of morphomics.

KW - ICU-acquired weakness

KW - Morphomics

KW - Sarcopenia

KW - Sepsis

KW - Tendon

UR - http://www.scopus.com/inward/record.url?scp=85054561990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054561990&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2018.09.010

DO - 10.1016/j.jss.2018.09.010

M3 - Article

VL - 234

SP - 210

EP - 216

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

ER -