Computed tomography assessment of ablation zone enhancement in patients with early-stage lung cancer after Stereotactic ablative radiotherapy

William Moore, Yair Chaya, Ammar Chaudhry, Britney Depasquale, Samantha Glass, Susan Lee, James Shin, George Mikhail, Priya Bhattacharji, Bong Kim, Thomas Bilfinger

Research output: Contribution to journalArticle

Abstract

Introduction: Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. Materials and Methods: In this retrospective designed Institutional Review Board-approved study, follow-up contrast-enhanced computed tomography (CT) exams were performed on sixty one patients to evaluate enhancement pattern in the ablation zone at 1, 3, 6, and 12 months after SABR. Results: Eleven patients had recurrence within the ablation zone after SABR. The postcontrast enhancement in the recurrence group showed a washin and washout phenomenon, whereas the radiation-induced lung injury group showed continuous enhancement suggesting an inflammatory process. Conclusions: The textural feature of the ablation zone of enhancement and perfusion as demonstrated in computed tomography nodule enhancement may allow early differentiation of recurrence from radiationinduced lung injury in patients' status after SABR or primary lung cancer.

Original languageEnglish (US)
Pages (from-to)804-809
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume39
Issue number5
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Lung Neoplasms
Radiotherapy
Tomography
Recurrence
Lung Injury
Research Ethics Committees
Perfusion
Radiation
Therapeutics

Keywords

  • Ablation
  • CT
  • Early-stage lung cancer
  • SABR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Computed tomography assessment of ablation zone enhancement in patients with early-stage lung cancer after Stereotactic ablative radiotherapy. / Moore, William; Chaya, Yair; Chaudhry, Ammar; Depasquale, Britney; Glass, Samantha; Lee, Susan; Shin, James; Mikhail, George; Bhattacharji, Priya; Kim, Bong; Bilfinger, Thomas.

In: Journal of Computer Assisted Tomography, Vol. 39, No. 5, 01.09.2015, p. 804-809.

Research output: Contribution to journalArticle

Moore, William ; Chaya, Yair ; Chaudhry, Ammar ; Depasquale, Britney ; Glass, Samantha ; Lee, Susan ; Shin, James ; Mikhail, George ; Bhattacharji, Priya ; Kim, Bong ; Bilfinger, Thomas. / Computed tomography assessment of ablation zone enhancement in patients with early-stage lung cancer after Stereotactic ablative radiotherapy. In: Journal of Computer Assisted Tomography. 2015 ; Vol. 39, No. 5. pp. 804-809.
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AU - Glass, Samantha

AU - Lee, Susan

AU - Shin, James

AU - Mikhail, George

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