Abstract
Introduction: Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. Materials and Methods: In this retrospective designed Institutional Review Board-approved study, follow-up contrast-enhanced computed tomography (CT) exams were performed on sixty one patients to evaluate enhancement pattern in the ablation zone at 1, 3, 6, and 12 months after SABR. Results: Eleven patients had recurrence within the ablation zone after SABR. The postcontrast enhancement in the recurrence group showed a washin and washout phenomenon, whereas the radiation-induced lung injury group showed continuous enhancement suggesting an inflammatory process. Conclusions: The textural feature of the ablation zone of enhancement and perfusion as demonstrated in computed tomography nodule enhancement may allow early differentiation of recurrence from radiationinduced lung injury in patients' status after SABR or primary lung cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 804-809 |
| Number of pages | 6 |
| Journal | Journal of Computer Assisted Tomography |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2015 |
| Externally published | Yes |
Fingerprint
Keywords
- Ablation
- CT
- Early-stage lung cancer
- SABR
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
Cite this
Computed tomography assessment of ablation zone enhancement in patients with early-stage lung cancer after Stereotactic ablative radiotherapy. / Moore, William; Chaya, Yair; Chaudhry, Ammar; Depasquale, Britney; Glass, Samantha; Lee, Susan; Shin, James; Mikhail, George; Bhattacharji, Priya; Kim, Bong; Bilfinger, Thomas.
In: Journal of Computer Assisted Tomography, Vol. 39, No. 5, 01.09.2015, p. 804-809.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Computed tomography assessment of ablation zone enhancement in patients with early-stage lung cancer after Stereotactic ablative radiotherapy
AU - Moore, William
AU - Chaya, Yair
AU - Chaudhry, Ammar
AU - Depasquale, Britney
AU - Glass, Samantha
AU - Lee, Susan
AU - Shin, James
AU - Mikhail, George
AU - Bhattacharji, Priya
AU - Kim, Bong
AU - Bilfinger, Thomas
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Introduction: Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. Materials and Methods: In this retrospective designed Institutional Review Board-approved study, follow-up contrast-enhanced computed tomography (CT) exams were performed on sixty one patients to evaluate enhancement pattern in the ablation zone at 1, 3, 6, and 12 months after SABR. Results: Eleven patients had recurrence within the ablation zone after SABR. The postcontrast enhancement in the recurrence group showed a washin and washout phenomenon, whereas the radiation-induced lung injury group showed continuous enhancement suggesting an inflammatory process. Conclusions: The textural feature of the ablation zone of enhancement and perfusion as demonstrated in computed tomography nodule enhancement may allow early differentiation of recurrence from radiationinduced lung injury in patients' status after SABR or primary lung cancer.
AB - Introduction: Stereotactic ablative radiotherapy (SABR) offers a curative treatment for lung cancer in patients who are marginal surgical candidates. However, unlike traditional surgery the lung cancer remains in place after treatment. Thus, imaging follow-up for evaluation of recurrence is of paramount importance. Materials and Methods: In this retrospective designed Institutional Review Board-approved study, follow-up contrast-enhanced computed tomography (CT) exams were performed on sixty one patients to evaluate enhancement pattern in the ablation zone at 1, 3, 6, and 12 months after SABR. Results: Eleven patients had recurrence within the ablation zone after SABR. The postcontrast enhancement in the recurrence group showed a washin and washout phenomenon, whereas the radiation-induced lung injury group showed continuous enhancement suggesting an inflammatory process. Conclusions: The textural feature of the ablation zone of enhancement and perfusion as demonstrated in computed tomography nodule enhancement may allow early differentiation of recurrence from radiationinduced lung injury in patients' status after SABR or primary lung cancer.
KW - Ablation
KW - CT
KW - Early-stage lung cancer
KW - SABR
UR - http://www.scopus.com/inward/record.url?scp=84941901825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941901825&partnerID=8YFLogxK
U2 - 10.1097/RCT.0000000000000262
DO - 10.1097/RCT.0000000000000262
M3 - Article
C2 - 25974720
AN - SCOPUS:84941901825
VL - 39
SP - 804
EP - 809
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
SN - 0363-8715
IS - 5
ER -