Computed Tomographic Perfusion Improves Diagnostic Power of Coronary Computed Tomographic Angiography in Women: Analysis of the CORE320 Trial (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion) According to Gender

Ashritha Penagaluri, Angela Y. Higgins, Andrea L. Vavere, Julie M Miller, Armin Zadeh, Aisha Betoko, Chloe Steveson, Elke Zimmermann, Christopher Cox, Carlos E. Rochitte, Marc Dewey, Klaus F. Kofoed, Hiroyuki Niinuma, Marcelo F. Di Carli, Joao Lima, Marcus Y. Chen

Research output: Contribution to journalArticle

Abstract

Background-Coronary computed tomographic angiography (CTA) and myocardial perfusion imaging (CTP) is a validated approach for detection and exclusion of flow-limiting coronary artery disease (CAD), but little data are available on gender-specific performance of these modalities. In this study, we aimed to evaluate the diagnostic accuracy of combined coronary CTA and CTP in detecting flow-limiting CAD in women compared with men. Methods and Results-Three hundred and eighty-one patients who underwent both CTA-CTP and single-photon emission computed tomography myocardial perfusion imaging preceding invasive coronary angiography as part of the CORE320 multicenter study (Coronary Artery Evaluation Using 320-row Multidetector Computed Tomography Angiography and Myocardial Perfusion) were included in this ancillary study. All 4 image modalities were analyzed in blinded, independent core laboratories. Prevalence of flow-limiting CAD defined by invasive coronary angiography equal to 50% or greater with an associated single-photon emission computed tomography myocardial perfusion imaging defect was 45% (114/252) and 23% (30/129) in males and females, respectively. Patient-based diagnostic accuracy defined by the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone in females was 0.83 (0.75-0.89) and for CTA-CTP was 0.92 (0.86-0.97; P=0.003) compared with men where the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone was 0.82 (0.77-0.87) and for CTA-CTP was 0.84 (0.80-0.89; P=0.29). Conclusions-The combination of CTA-CTP was performed similarly in men and women for identifying flow-limiting coronary stenosis; however, in women, CTP had incremental value over CTA alone, which was not the case in men.

Original languageEnglish (US)
Article numbere005189
JournalCirculation: Cardiovascular Imaging
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2016

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Cytidine Triphosphate
Coronary Vessels
Angiography
Perfusion
Coronary Artery Disease
Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Coronary Angiography
Computed Tomography Angiography
Coronary Stenosis
Multicenter Studies

Keywords

  • Computed tomography
  • coronary angiography
  • gender
  • myocardial perfusion imaging
  • women

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Computed Tomographic Perfusion Improves Diagnostic Power of Coronary Computed Tomographic Angiography in Women : Analysis of the CORE320 Trial (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion) According to Gender. / Penagaluri, Ashritha; Higgins, Angela Y.; Vavere, Andrea L.; Miller, Julie M; Zadeh, Armin; Betoko, Aisha; Steveson, Chloe; Zimmermann, Elke; Cox, Christopher; Rochitte, Carlos E.; Dewey, Marc; Kofoed, Klaus F.; Niinuma, Hiroyuki; Di Carli, Marcelo F.; Lima, Joao; Chen, Marcus Y.

In: Circulation: Cardiovascular Imaging, Vol. 9, No. 11, e005189, 01.11.2016.

Research output: Contribution to journalArticle

Penagaluri, Ashritha ; Higgins, Angela Y. ; Vavere, Andrea L. ; Miller, Julie M ; Zadeh, Armin ; Betoko, Aisha ; Steveson, Chloe ; Zimmermann, Elke ; Cox, Christopher ; Rochitte, Carlos E. ; Dewey, Marc ; Kofoed, Klaus F. ; Niinuma, Hiroyuki ; Di Carli, Marcelo F. ; Lima, Joao ; Chen, Marcus Y. / Computed Tomographic Perfusion Improves Diagnostic Power of Coronary Computed Tomographic Angiography in Women : Analysis of the CORE320 Trial (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion) According to Gender. In: Circulation: Cardiovascular Imaging. 2016 ; Vol. 9, No. 11.
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abstract = "Background-Coronary computed tomographic angiography (CTA) and myocardial perfusion imaging (CTP) is a validated approach for detection and exclusion of flow-limiting coronary artery disease (CAD), but little data are available on gender-specific performance of these modalities. In this study, we aimed to evaluate the diagnostic accuracy of combined coronary CTA and CTP in detecting flow-limiting CAD in women compared with men. Methods and Results-Three hundred and eighty-one patients who underwent both CTA-CTP and single-photon emission computed tomography myocardial perfusion imaging preceding invasive coronary angiography as part of the CORE320 multicenter study (Coronary Artery Evaluation Using 320-row Multidetector Computed Tomography Angiography and Myocardial Perfusion) were included in this ancillary study. All 4 image modalities were analyzed in blinded, independent core laboratories. Prevalence of flow-limiting CAD defined by invasive coronary angiography equal to 50{\%} or greater with an associated single-photon emission computed tomography myocardial perfusion imaging defect was 45{\%} (114/252) and 23{\%} (30/129) in males and females, respectively. Patient-based diagnostic accuracy defined by the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone in females was 0.83 (0.75-0.89) and for CTA-CTP was 0.92 (0.86-0.97; P=0.003) compared with men where the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone was 0.82 (0.77-0.87) and for CTA-CTP was 0.84 (0.80-0.89; P=0.29). Conclusions-The combination of CTA-CTP was performed similarly in men and women for identifying flow-limiting coronary stenosis; however, in women, CTP had incremental value over CTA alone, which was not the case in men.",
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T2 - Analysis of the CORE320 Trial (Coronary Artery Evaluation Using 320-Row Multidetector Computed Tomography Angiography and Myocardial Perfusion) According to Gender

AU - Penagaluri, Ashritha

AU - Higgins, Angela Y.

AU - Vavere, Andrea L.

AU - Miller, Julie M

AU - Zadeh, Armin

AU - Betoko, Aisha

AU - Steveson, Chloe

AU - Zimmermann, Elke

AU - Cox, Christopher

AU - Rochitte, Carlos E.

AU - Dewey, Marc

AU - Kofoed, Klaus F.

AU - Niinuma, Hiroyuki

AU - Di Carli, Marcelo F.

AU - Lima, Joao

AU - Chen, Marcus Y.

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N2 - Background-Coronary computed tomographic angiography (CTA) and myocardial perfusion imaging (CTP) is a validated approach for detection and exclusion of flow-limiting coronary artery disease (CAD), but little data are available on gender-specific performance of these modalities. In this study, we aimed to evaluate the diagnostic accuracy of combined coronary CTA and CTP in detecting flow-limiting CAD in women compared with men. Methods and Results-Three hundred and eighty-one patients who underwent both CTA-CTP and single-photon emission computed tomography myocardial perfusion imaging preceding invasive coronary angiography as part of the CORE320 multicenter study (Coronary Artery Evaluation Using 320-row Multidetector Computed Tomography Angiography and Myocardial Perfusion) were included in this ancillary study. All 4 image modalities were analyzed in blinded, independent core laboratories. Prevalence of flow-limiting CAD defined by invasive coronary angiography equal to 50% or greater with an associated single-photon emission computed tomography myocardial perfusion imaging defect was 45% (114/252) and 23% (30/129) in males and females, respectively. Patient-based diagnostic accuracy defined by the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone in females was 0.83 (0.75-0.89) and for CTA-CTP was 0.92 (0.86-0.97; P=0.003) compared with men where the area under the receiver operating curve for detecting flow-limiting CAD by CTA alone was 0.82 (0.77-0.87) and for CTA-CTP was 0.84 (0.80-0.89; P=0.29). Conclusions-The combination of CTA-CTP was performed similarly in men and women for identifying flow-limiting coronary stenosis; however, in women, CTP had incremental value over CTA alone, which was not the case in men.

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KW - gender

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