Computed simultaneous imaging of multiple functional biomarkers

Yue Wang, Rujirutana Srikanchana, Jianhua Xuan, Zsolt Szabo, Peter Choyke

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic functional imaging techniques promise powerful tools for the visualization and elucidation of important disease-causing physiologic processes in living tissue. Most applications aim to find temporal-spatial patterns associated with different disease stages. When multiple functional biomarkers are targeted, imagery signals often represent a composite of more than one distinct functional source independent of spatial resolution. Here we introduce a hybrid blind source separation method that is able to factorize underlying source images and time activity curves from dynamically mixed image sequence. The algorithm is based on a compartment latent variable model, whose parameters are estimated using multivariate clustering and/or independent component analysis. We demonstrate the principle of the approach on tumor microvascular characterization using dynamic contrast-enhanced magnetic resonance imaging for monitoring response to anti-angiogenic therapies.

Original languageEnglish (US)
Title of host publication2004 2nd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationMacro to Nano
Pages225-228
Number of pages4
StatePublished - Dec 1 2004
Event2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano - Arlington, VA, United States
Duration: Apr 15 2004Apr 18 2004

Publication series

Name2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Volume1

Other

Other2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
CountryUnited States
CityArlington, VA
Period4/15/044/18/04

ASJC Scopus subject areas

  • Engineering(all)

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    Wang, Y., Srikanchana, R., Xuan, J., Szabo, Z., & Choyke, P. (2004). Computed simultaneous imaging of multiple functional biomarkers. In 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (pp. 225-228). (2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano; Vol. 1).