TY - GEN
T1 - Computed simultaneous imaging of multiple functional biomarkers
AU - Wang, Yue
AU - Srikanchana, Rujirutana
AU - Xuan, Jianhua
AU - Szabo, Zsolt
AU - Choyke, Peter
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Dynamic functional imaging techniques promise powerful tools for the visualization and elucidation of important disease-causing physiologic processes in living tissue. Most applications aim to find temporal-spatial patterns associated with different disease stages. When multiple functional biomarkers are targeted, imagery signals often represent a composite of more than one distinct functional source independent of spatial resolution. Here we introduce a hybrid blind source separation method that is able to factorize underlying source images and time activity curves from dynamically mixed image sequence. The algorithm is based on a compartment latent variable model, whose parameters are estimated using multivariate clustering and/or independent component analysis. We demonstrate the principle of the approach on tumor microvascular characterization using dynamic contrast-enhanced magnetic resonance imaging for monitoring response to anti-angiogenic therapies.
AB - Dynamic functional imaging techniques promise powerful tools for the visualization and elucidation of important disease-causing physiologic processes in living tissue. Most applications aim to find temporal-spatial patterns associated with different disease stages. When multiple functional biomarkers are targeted, imagery signals often represent a composite of more than one distinct functional source independent of spatial resolution. Here we introduce a hybrid blind source separation method that is able to factorize underlying source images and time activity curves from dynamically mixed image sequence. The algorithm is based on a compartment latent variable model, whose parameters are estimated using multivariate clustering and/or independent component analysis. We demonstrate the principle of the approach on tumor microvascular characterization using dynamic contrast-enhanced magnetic resonance imaging for monitoring response to anti-angiogenic therapies.
UR - http://www.scopus.com/inward/record.url?scp=17144382475&partnerID=8YFLogxK
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M3 - Conference contribution
AN - SCOPUS:17144382475
SN - 0780383885
T3 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
SP - 225
EP - 228
BT - 2004 2nd IEEE International Symposium on Biomedical Imaging
T2 - 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano
Y2 - 15 April 2004 through 18 April 2004
ER -