Computational models of VEGF-associated angiogenic processes in cancer

Marianne O. Stefanini, Amina A. Qutub, Feilim Mac Gabhann, Aleksander S. Popel

Research output: Contribution to journalArticlepeer-review

Abstract

Tumour angiogenesis allows a growing mass of cancer cells to overcome oxygen diffusion limitation and to increase cell survival. The growth of capillaries from pre-existing blood vessels is the result of numerous signalling cascades involving different molecules and of cellular events involving multiple cell and tissue types. Computational models offer insight into the mechanisms governing angiogenesis and provide quantitative information on parameters difficult to assess by experiments alone. In this article, we summarize results from computational models of tumour angiogenic processes with a focus on the molecular-detailed vascular endothelial growth factor-associated models that have been developed in our laboratory, spanning multiple scales from the molecular to whole body.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalMathematical Medicine and Biology
Volume29
Issue number1
DOIs
StatePublished - Mar 1 2012

Keywords

  • Angiogenesis
  • Computational biology
  • Systems biology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Pharmacology
  • Applied Mathematics

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