Computational modeling and analysis of intracardiac flows in simple models of the left ventricle

X. Zheng, J. H. Seo, V. Vedula, T. Abraham, R. Mittal

Research output: Contribution to journalArticle

Abstract

Computational modeling is used to study intracardiac flows in normal and diseased left-ventricles. The left-ventricle is modeled as a semi-prolate-spheroid, and the wall motion is driven by a prescribed ventricular volume-change that consists of five stages: early (E) filling, diastasis, atrial (A) filling, isovolumetric contraction (ISVC) and systole. Simulations are carried out with a parallelized immersed-boundary flow solver that allows us to simulate this flow on a stationary Cartesian grid. The ventricular flow behavior is analyzed to reveal blood flow patterns during both filling and ejection for normal ventricles, as well as ventricles with diastolic and systolic dysfunctions. Impaired relaxation associated with early-stage diastolic dysfunction is modeled by a reduced E/A ratio, and the systolic dysfunction addressed here is obstructive hypertrophic cardiomyopathy (HOCM), where the thickened ventricular septum in the basal region obstructs the outflow tract. Simulations are also performed to study the effect of septal myectomy on the ventricular flow. We examine the characteristic features of these various conditions including vortex dynamics, 'virtual' color M-mode cardiography as well as mixing and transport of blood through the left-ventricle during the entire cardiac cycle.

Original languageEnglish (US)
Pages (from-to)31-39
Number of pages9
JournalEuropean Journal of Mechanics, B/Fluids
Volume35
DOIs
StatePublished - Sep 2012

Fingerprint

Left Ventricle
Computational Analysis
Computational Modeling
cardiography
systole
Immersed Boundary
Cardiomyopathy
Systole
Vortex Dynamics
prolate spheroids
septum
Cartesian Grid
Model
Flow Pattern
blood flow
Blood Flow
ejection
Cardiac
contraction
blood

Keywords

  • Cardiac flow
  • Diastolic heart dysfunction
  • Hemodynamics
  • Hypertrophic obstructive cardiomyopathy
  • Immersed boundary method
  • Septal myectomy

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Mathematical Physics

Cite this

Computational modeling and analysis of intracardiac flows in simple models of the left ventricle. / Zheng, X.; Seo, J. H.; Vedula, V.; Abraham, T.; Mittal, R.

In: European Journal of Mechanics, B/Fluids, Vol. 35, 09.2012, p. 31-39.

Research output: Contribution to journalArticle

Zheng, X. ; Seo, J. H. ; Vedula, V. ; Abraham, T. ; Mittal, R. / Computational modeling and analysis of intracardiac flows in simple models of the left ventricle. In: European Journal of Mechanics, B/Fluids. 2012 ; Vol. 35. pp. 31-39.
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