Computational model of the modulation of gene expression following DNA damage

F. A. Cucinotta, John F Dicello, H. Nikjoo, R. Cherubini, R. Cherubini, D. T. Goodhead, H. G. Menzel, A. Ottolenghi

Research output: Contribution to journalArticle

Abstract

High linear energy transfer (LET) radiation, such as heavy ions or neutrons, has an increased biological effectiveness compared to X rays for gene mutation, genomic instability, and carcinogenesis. In the traditional paradigm, mutations or chromosomal aberrations are causative of late effects. However, in recent years experimental evidence has demonstrated the important role of the description of the modification of gene expression by radiation in understanding the mechanisms of radiation action. In this report, approaches are discussed to the mathematical description of mRNA and protein expression kinetics following DNA damage. Several hypotheses for models of radiation modulation of protein expression are discussed including possible non-linear processes that evolve from the linear dose responses that follow the initial DNA damage produced by radiation.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalRadiation Protection Dosimetry
Volume99
Issue number1-4
StatePublished - 2002

Fingerprint

gene expression
Gene expression
DNA Damage
DNA
deoxyribonucleic acid
Modulation
Radiation
damage
Gene Expression
modulation
radiation
mutations
proteins
Proteins
Heavy Ions
Linear Energy Transfer
linear energy transfer (LET)
Mutation
Genomic Instability
Neutrons

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Cucinotta, F. A., Dicello, J. F., Nikjoo, H., Cherubini, R., Cherubini, R., Goodhead, D. T., ... Ottolenghi, A. (2002). Computational model of the modulation of gene expression following DNA damage. Radiation Protection Dosimetry, 99(1-4), 85-90.

Computational model of the modulation of gene expression following DNA damage. / Cucinotta, F. A.; Dicello, John F; Nikjoo, H.; Cherubini, R.; Cherubini, R.; Goodhead, D. T.; Menzel, H. G.; Ottolenghi, A.

In: Radiation Protection Dosimetry, Vol. 99, No. 1-4, 2002, p. 85-90.

Research output: Contribution to journalArticle

Cucinotta, FA, Dicello, JF, Nikjoo, H, Cherubini, R, Cherubini, R, Goodhead, DT, Menzel, HG & Ottolenghi, A 2002, 'Computational model of the modulation of gene expression following DNA damage', Radiation Protection Dosimetry, vol. 99, no. 1-4, pp. 85-90.
Cucinotta FA, Dicello JF, Nikjoo H, Cherubini R, Cherubini R, Goodhead DT et al. Computational model of the modulation of gene expression following DNA damage. Radiation Protection Dosimetry. 2002;99(1-4):85-90.
Cucinotta, F. A. ; Dicello, John F ; Nikjoo, H. ; Cherubini, R. ; Cherubini, R. ; Goodhead, D. T. ; Menzel, H. G. ; Ottolenghi, A. / Computational model of the modulation of gene expression following DNA damage. In: Radiation Protection Dosimetry. 2002 ; Vol. 99, No. 1-4. pp. 85-90.
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