Computational infrastructures for data and knowledge management in systems biology

Fotis Georgatos, Stéphane Ballereau, Johann Pellet, Moustafa Ghanem, Nathan Price, Leroy Hood, Yi Ke Guo, Dominique Boutigny, Charles Auffray, Rudi Balling, Reinhard Schneider

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The volume, complexity and heterogeneity of data originating from high throughput functional genomics technologies have created challenges and opportunities for Information technology (IT) departments. These increased demands have also led to increasing costs for IT infrastructure such as necessary computing power and storage devices, as well as further costs for manpower effort, required for maintenance. This chapter describes some of the challenges for computational analysis infrastructure, including bottlenecks and most pressing needs that have to be addressed to effectively support the development of systems biology and its application in medicine.

Original languageEnglish (US)
Title of host publicationSystems Biology
Subtitle of host publicationIntegrative Biology and Simulation Tools
PublisherSpringer Netherlands
Pages377-397
Number of pages21
ISBN (Electronic)9789400768031
ISBN (Print)9789400768024
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Bioinformatics
  • Cloud
  • Cluster
  • Computational infrastructures
  • Computational science
  • Computing
  • Data centers
  • Data management
  • Desktop grid
  • E-science
  • Grid
  • High performance computing
  • Information technology
  • Infrastructures
  • Knowledge management
  • Scientific computing
  • Storage
  • Systems biology
  • Translational research

ASJC Scopus subject areas

  • Medicine(all)

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