Computational analysis of noncoding RNAs

Stefan Washietl, Sebastian Will, David A. Hendrix, Loyal A. Goff, John L. Rinn, Bonnie Berger, Manolis Kellis

Research output: Contribution to journalReview articlepeer-review

Abstract

Noncoding RNAs have emerged as important key players in the cell. Understanding their surprisingly diverse range of functions is challenging for experimental and computational biology. Here, we review computational methods to analyze noncoding RNAs. The topics covered include basic and advanced techniques to predict RNA structures, annotation of noncoding RNAs in genomic data, mining RNA-seq data for novel transcripts and prediction of transcript structures, computational aspects of microRNAs, and database resources. These authors contributed equally WIREs RNA 2012.

Original languageEnglish (US)
Pages (from-to)759-778
Number of pages20
JournalWiley Interdisciplinary Reviews: RNA
Volume3
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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