Compressibility of perfused passive myocardium

Frank C.P. Yin, Charles C.H. Chan, Robert M. Judd

Research output: Contribution to journalArticle

Abstract

In most theoretical analyses of the heart, the tissue has been assumed to be incompressible. Because the myocardium is extensively perfused with distensible vessels, increasing the stiffness of the surrounding tissue, as with contraction or passive stretching, should decrease the volume of fluid in these vessels. Using a digital subtraction angiographic method, we quantified the amount of vascular volume extruded from six passive, perfused canine interventricular septa during cyclic biaxial loading from 300 to 900 g force. At pressures from 0 to 120 mmHg the amount of fluid extruded during a loading cycle varied from 2 to 4 ml/100 g tissue at 0 and 120 mmHg, respectively. This volume change increased with perfusion pressure and was significantly greater at 120 than at 0, 30, or 60 mmHg. The amount of fluid extruded was on the same order as that estimated during active contraction or with a 60-mmHg change in perfusion pressure. The finding that perfused myocardium is compressible implies that results from existing analyses of the heart assuming incompressibility are not realistic. Such analyses must account for compressibility with, e.g., mixture theory or other similar approaches.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume40
Issue number5
StatePublished - Nov 1 1996

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Myocardium
Pressure
Perfusion
Muscle Stretching Exercises
Blood Vessels
Canidae

Keywords

  • Heart mechanics
  • Incompressible materials
  • Mixture theory
  • Myocardial tissue
  • Myocardial vascular volume

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Compressibility of perfused passive myocardium. / Yin, Frank C.P.; Chan, Charles C.H.; Judd, Robert M.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 40, No. 5, 01.11.1996.

Research output: Contribution to journalArticle

Yin, Frank C.P. ; Chan, Charles C.H. ; Judd, Robert M. / Compressibility of perfused passive myocardium. In: American Journal of Physiology - Heart and Circulatory Physiology. 1996 ; Vol. 40, No. 5.
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