Abstract
A radionuclide methodology and reference values have been developed for a single gastrointestinal transit study including esophageal transit, liquid and solid gastric emptying, and small- and large-bowel transit, using 111In-diethylenetriaminepentaacetic acid (DTPA) with the standardized 99mTc-labeled solid meal. Methods: Eighteen healthy subjects and 18 patients were investigated. The esophageal transit study was performed with 3.7 MBq (0.1 mCi) of 111In-DTPA in 15 mL of water. A liquid-only 30-min gastric-emptying study followed, with ingestion of 3.7 MBq (0.1 mCi) of 111In-DTPA in 300 mL of water. Then, a simultaneous solid-liquid emptying study was acquired after ingestion of a solid 99mTc-sulfur colloid-labeled meal and 7.4 MBq (0.2 mCi) of 111In-DTPA in 120 mL of water. Images were acquired intermittently for 4 h. Additional 111In images were acquired at 5 and 6 h to measure small-bowel transit, and at 24, 48, and 72 h for large-bowel transit. Results: Reference values were determined for esophageal transit (transit time, percentage emptying at 10 s), liquid-only gastric emptying (emptying half-time), liquid and solid emptying in a dual-phase solid-liquid study (emptying half-time and percentage emptying at 1, 2, 3, and 4 h), small-bowel transit index (percentage transit to ileocecal valve at 6 h), and colonic transit (geometric center and percentage colonic emptying) at 24, 48, and 72 h. Results from the first 18 patients found abnormal transit in 72% (13/18); clinical management changed in 61% (11/18). Conclusion: We have developed a radionuclide methodology and derived reference values for a comprehensive gastrointestinal transit study using 111In-DTPA with the standardized 99mTc-labeled solid meal. Our initial clinical experience suggests clinical value.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 721-727 |
| Number of pages | 7 |
| Journal | Journal of Nuclear Medicine |
| Volume | 56 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2015 |
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Keywords
- Esophageal scintigraphy
- Gastric emptying
- Gastrointestinal scintigraphy
- Intestinal transit
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
Cite this
Comprehensive radionuclide esophagogastrointestinal transit study : Methodology, reference values, and initial clinical experience. / Antoniou, Alexander J.; Raja, Shreya; El-Khouli, Riham; Mena, Esther; Lodge, Martin; Wahl, Richard L.; Clarke, John O.; Pasricha, Pankaj Jay; Ziessman, Harvey.
In: Journal of Nuclear Medicine, Vol. 56, No. 5, 01.05.2015, p. 721-727.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive radionuclide esophagogastrointestinal transit study
T2 - Methodology, reference values, and initial clinical experience
AU - Antoniou, Alexander J.
AU - Raja, Shreya
AU - El-Khouli, Riham
AU - Mena, Esther
AU - Lodge, Martin
AU - Wahl, Richard L.
AU - Clarke, John O.
AU - Pasricha, Pankaj Jay
AU - Ziessman, Harvey
PY - 2015/5/1
Y1 - 2015/5/1
N2 - A radionuclide methodology and reference values have been developed for a single gastrointestinal transit study including esophageal transit, liquid and solid gastric emptying, and small- and large-bowel transit, using 111In-diethylenetriaminepentaacetic acid (DTPA) with the standardized 99mTc-labeled solid meal. Methods: Eighteen healthy subjects and 18 patients were investigated. The esophageal transit study was performed with 3.7 MBq (0.1 mCi) of 111In-DTPA in 15 mL of water. A liquid-only 30-min gastric-emptying study followed, with ingestion of 3.7 MBq (0.1 mCi) of 111In-DTPA in 300 mL of water. Then, a simultaneous solid-liquid emptying study was acquired after ingestion of a solid 99mTc-sulfur colloid-labeled meal and 7.4 MBq (0.2 mCi) of 111In-DTPA in 120 mL of water. Images were acquired intermittently for 4 h. Additional 111In images were acquired at 5 and 6 h to measure small-bowel transit, and at 24, 48, and 72 h for large-bowel transit. Results: Reference values were determined for esophageal transit (transit time, percentage emptying at 10 s), liquid-only gastric emptying (emptying half-time), liquid and solid emptying in a dual-phase solid-liquid study (emptying half-time and percentage emptying at 1, 2, 3, and 4 h), small-bowel transit index (percentage transit to ileocecal valve at 6 h), and colonic transit (geometric center and percentage colonic emptying) at 24, 48, and 72 h. Results from the first 18 patients found abnormal transit in 72% (13/18); clinical management changed in 61% (11/18). Conclusion: We have developed a radionuclide methodology and derived reference values for a comprehensive gastrointestinal transit study using 111In-DTPA with the standardized 99mTc-labeled solid meal. Our initial clinical experience suggests clinical value.
AB - A radionuclide methodology and reference values have been developed for a single gastrointestinal transit study including esophageal transit, liquid and solid gastric emptying, and small- and large-bowel transit, using 111In-diethylenetriaminepentaacetic acid (DTPA) with the standardized 99mTc-labeled solid meal. Methods: Eighteen healthy subjects and 18 patients were investigated. The esophageal transit study was performed with 3.7 MBq (0.1 mCi) of 111In-DTPA in 15 mL of water. A liquid-only 30-min gastric-emptying study followed, with ingestion of 3.7 MBq (0.1 mCi) of 111In-DTPA in 300 mL of water. Then, a simultaneous solid-liquid emptying study was acquired after ingestion of a solid 99mTc-sulfur colloid-labeled meal and 7.4 MBq (0.2 mCi) of 111In-DTPA in 120 mL of water. Images were acquired intermittently for 4 h. Additional 111In images were acquired at 5 and 6 h to measure small-bowel transit, and at 24, 48, and 72 h for large-bowel transit. Results: Reference values were determined for esophageal transit (transit time, percentage emptying at 10 s), liquid-only gastric emptying (emptying half-time), liquid and solid emptying in a dual-phase solid-liquid study (emptying half-time and percentage emptying at 1, 2, 3, and 4 h), small-bowel transit index (percentage transit to ileocecal valve at 6 h), and colonic transit (geometric center and percentage colonic emptying) at 24, 48, and 72 h. Results from the first 18 patients found abnormal transit in 72% (13/18); clinical management changed in 61% (11/18). Conclusion: We have developed a radionuclide methodology and derived reference values for a comprehensive gastrointestinal transit study using 111In-DTPA with the standardized 99mTc-labeled solid meal. Our initial clinical experience suggests clinical value.
KW - Esophageal scintigraphy
KW - Gastric emptying
KW - Gastrointestinal scintigraphy
KW - Intestinal transit
UR - http://www.scopus.com/inward/record.url?scp=84929464065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929464065&partnerID=8YFLogxK
U2 - 10.2967/jnumed.114.152074
DO - 10.2967/jnumed.114.152074
M3 - Article
C2 - 25766893
AN - SCOPUS:84929464065
VL - 56
SP - 721
EP - 727
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 5
ER -