Comprehensive molecular tumor profiling in radiation oncology: How it could be used for precision medicine

Iris Eke, Adeola Y. Makinde, Molykutty J. Aryankalayil, Mansoor M. Ahmed, C. Norman Coleman

Research output: Contribution to journalReview articlepeer-review

Abstract

New technologies enabling the analysis of various molecules, including DNA, RNA, proteins and small metabolites, can aid in understanding the complex molecular processes in cancer cells. In particular, for the use of novel targeted therapeutics, elucidation of the mechanisms leading to cell death or survival is crucial to eliminate tumor resistance and optimize therapeutic efficacy. While some techniques, such as genomic analysis for identifying specific gene mutations or epigenetic testing of promoter methylation, are already in clinical use, other “omics-based” assays are still evolving. Here, we provide an overview of the current status of molecular profiling methods, including promising research strategies, as well as possible challenges, and their emerging role in radiation oncology.

Original languageEnglish (US)
Pages (from-to)118-126
Number of pages9
JournalCancer Letters
Volume382
Issue number1
DOIs
StatePublished - Nov 1 2016

Keywords

  • Molecular profiling
  • Precision medicine
  • Radiation oncology
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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