Abstract
We performed a comprehensive meta-analysis of two recent, multicenter, randomized, and controlled trials of the investigational new drug Tavocept (vs. placebo or no Tavocept) in chemotherapy-naive patients with advanced non-small cell lung cancer (NSCLC) who were treated with taxane plus cisplatin therapy. Significant improvements in overall and l-year survival were observed, which were most apparent in patients with the adenocarcinoma subtype. The results of this meta-analysis support the view that Tavocept combined with taxane plus cisplatin first-line therapy may result in significant increases in overall and i-year survival in patients with primary adenocarcinoma of the lung. The results of this systematic meta-analysis were used for the design and scientific justification of an international, double-blind, and placebo-controlled phase III confirmatory trial of Tavocept in patients with advanced (stage IIIB/IV) primary adenocarcinoma of the lung treated with taxane plus cisplatin using a primary endpoint of overall survival.
Original language | English (US) |
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Pages (from-to) | 1-13 |
Number of pages | 13 |
Journal | Asia-Pacific Journal of Oncology and Hematology |
Volume | 2 |
Issue number | 1 |
State | Published - Feb 2010 |
Externally published | Yes |
Keywords
- Adenocarcinoma
- Antitumor enhancement
- BNP7787
- Chemoprotection
- Lung cancer
- Meta-analysis
- Survival
- Tavocept
ASJC Scopus subject areas
- Oncology
- Hematology