Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation

Gregory S X E Jefferis, Christopher J Potter, Alexander M. Chan, Elizabeth C. Marin, Torsten Rohlfing, Calvin R. Maurer, Liqun Luo

Research output: Contribution to journalArticle

Abstract

In Drosophila, ∼50 classes of olfactory receptor neurons (ORNs) send axons to 50 corresponding glomeruli in the antennal lobe. Uniglomerular projection neurons (PNs) relay olfactory information to the mushroom body (MB) and lateral horn (LH). Here, we combine single-cell labeling and image registration to create high-resolution, quantitative maps of the MB and LH for 35 input PN channels and several groups of LH neurons. We find (1) PN inputs to the MB are stereotyped as previously shown for the LH; (2) PN partners of ORNs from different sensillar groups are clustered in the LH; (3) fruit odors are represented mostly in the posterior-dorsal LH, whereas candidate pheromone-responsive PNs project to the anterior-ventral LH; (4) dendrites of single LH neurons each overlap with specific subsets of PN axons. Our results suggest that the LH is organized according to biological values of olfactory input.

Original languageEnglish (US)
Pages (from-to)1187-1203
Number of pages17
JournalCell
Volume128
Issue number6
DOIs
StatePublished - Mar 23 2007
Externally publishedYes

Fingerprint

Pheromones
Horns
Fruits
Drosophila
Neurons
Fruit
Mushroom Bodies
Olfactory Receptor Neurons
Odorant Receptors
Axons
Dendrites
Image registration
Odors
Labeling

Keywords

  • SYSNEURO

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Jefferis, G. S. X. E., Potter, C. J., Chan, A. M., Marin, E. C., Rohlfing, T., Maurer, C. R., & Luo, L. (2007). Comprehensive Maps of Drosophila Higher Olfactory Centers: Spatially Segregated Fruit and Pheromone Representation. Cell, 128(6), 1187-1203. https://doi.org/10.1016/j.cell.2007.01.040

Comprehensive Maps of Drosophila Higher Olfactory Centers : Spatially Segregated Fruit and Pheromone Representation. / Jefferis, Gregory S X E; Potter, Christopher J; Chan, Alexander M.; Marin, Elizabeth C.; Rohlfing, Torsten; Maurer, Calvin R.; Luo, Liqun.

In: Cell, Vol. 128, No. 6, 23.03.2007, p. 1187-1203.

Research output: Contribution to journalArticle

Jefferis, Gregory S X E ; Potter, Christopher J ; Chan, Alexander M. ; Marin, Elizabeth C. ; Rohlfing, Torsten ; Maurer, Calvin R. ; Luo, Liqun. / Comprehensive Maps of Drosophila Higher Olfactory Centers : Spatially Segregated Fruit and Pheromone Representation. In: Cell. 2007 ; Vol. 128, No. 6. pp. 1187-1203.
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