Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

Xiaohui Yan, Zhongyi Hu, Yi Feng, Xiaowen Hu, Jiao Yuan, Sihai D. Zhao, Youyou Zhang, Lu Yang, Weiwei Shan, Qun He, Lingling Fan, Lana E. Kandalaft, Janos L. Tanyi, Chunsheng Li, Chao Xing Yuan, Dongmei Zhang, Huiqing Yuan, Keqin Hua, Yiling Lu, Dionyssios KatsarosQihong Huang, Kathleen Montone, Yi Fan, George Coukos, Jeff Boyd, Anil K. Sood, Timothy Rebbeck, Gordon B. Mills, Chi V. Dang, Lin Zhang

Research output: Contribution to journalArticle

Abstract

The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.

Original languageEnglish (US)
Article number2143
Pages (from-to)529-540
Number of pages12
JournalCancer Cell
Volume28
Issue number4
DOIs
StatePublished - Oct 12 2015
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Yan, X., Hu, Z., Feng, Y., Hu, X., Yuan, J., Zhao, S. D., Zhang, Y., Yang, L., Shan, W., He, Q., Fan, L., Kandalaft, L. E., Tanyi, J. L., Li, C., Yuan, C. X., Zhang, D., Yuan, H., Hua, K., Lu, Y., ... Zhang, L. (2015). Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell, 28(4), 529-540. [2143]. https://doi.org/10.1016/j.ccell.2015.09.006