TY - JOUR
T1 - Comprehensive First-trimester prenatal assessment
AU - Miller, Jena
AU - Harman, Christopher
N1 - Funding Information:
Parts of this work were supported by the "Bundesministerium f?r Forschung und Technology" (03-E-8640-A).
PY - 2009
Y1 - 2009
N2 - Comprehensive first-trimester pregnancy evaluation is a work in progress. The evolution of screening strategies has distilled a combination of maternal factors, early pregnancy analytes in maternal serum, and fetal sonographic parameters into carefully derived risk assessment algorithms. This integrated approach, almost continually supplemented by new information derived from large population-based studies, individualizes assessment to each mother-placentafetus triad. Early and accurate, this assessment potentiates informed decision-making and prenatal management. Invasive testing can be limited to those at high risk, decreasing procedure-related losses of unaffected fetuses. Advance warning of pre-eclampsia and other placenta-based disorders allows stratification of care and opens new windows to prevention therapy. Viewing of anomalies, even complex congenital heart disease, using the steadily advancing three-and four-dimensional capabilities now available, allows prenatal diagnosis and intrauterine surgical management. Comprehensive risk assessment in early pregnancy is transforming prenatal care.
AB - Comprehensive first-trimester pregnancy evaluation is a work in progress. The evolution of screening strategies has distilled a combination of maternal factors, early pregnancy analytes in maternal serum, and fetal sonographic parameters into carefully derived risk assessment algorithms. This integrated approach, almost continually supplemented by new information derived from large population-based studies, individualizes assessment to each mother-placentafetus triad. Early and accurate, this assessment potentiates informed decision-making and prenatal management. Invasive testing can be limited to those at high risk, decreasing procedure-related losses of unaffected fetuses. Advance warning of pre-eclampsia and other placenta-based disorders allows stratification of care and opens new windows to prevention therapy. Viewing of anomalies, even complex congenital heart disease, using the steadily advancing three-and four-dimensional capabilities now available, allows prenatal diagnosis and intrauterine surgical management. Comprehensive risk assessment in early pregnancy is transforming prenatal care.
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U2 - 10.1542/neo.10-11-e538
DO - 10.1542/neo.10-11-e538
M3 - Article
AN - SCOPUS:77149154077
SN - 1526-9906
VL - 10
SP - e538-e549
JO - NeoReviews
JF - NeoReviews
IS - 11
ER -