Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder

Ernest M Mahone, Marin E. Ranta, Deana Crocetti, Jessica O'Brien, Walter E. Kaufmann, Martha Bridge Denckla, Stewart H Mostofsky

Research output: Contribution to journalArticle

Abstract

The current study examined regional frontal lobe volumes based on functionally relevant subdivisions in contemporaneously recruited samples of boys and girls with and without attention-deficit/hyperactivity disorder (ADHD). Forty-four boys (21 ADHD, 23 control) and 42 girls (21 ADHD, 21 control), ages 8-13 years, participated. Sulcal-gyral landmarks were used to manually delimit functionally relevant regions within the frontal lobe: primary motor cortex, anterior cingulate, deep white matter, premotor regions [supplementary motor complex (SMC), frontal eye field, lateral premotor cortex (LPM)], and prefrontal cortex (PFC) regions [medial PFC, dorsolateral PFC (DLPFC), inferior PFC, lateral orbitofrontal cortex (OFC), and medial OFC]. Compared to sex-matched controls, boys and girls with ADHD showed reduced volumes (gray and white matter) in the left SMC. Conversely, girls (but not boys) with ADHD showed reduced gray matter volume in left LPM; while boys (but not girls) with ADHD showed reduced white matter volume in left medial PFC. Reduced left SMC gray matter volumes predicted increased go/no-go commission rate in children with ADHD. Reduced left LPM gray matter volumes predicted increased go/no-go variability, but only among girls with ADHD. Results highlight different patterns of anomalous frontal lobe development among boys and girls with ADHD beyond that detected by measuring whole lobar volumes.

Original languageEnglish (US)
Pages (from-to)1047-1057
Number of pages11
JournalJournal of the International Neuropsychological Society
Volume17
Issue number6
DOIs
StatePublished - Nov 2011

Fingerprint

ADHD
Attention Deficit Disorder with Hyperactivity
Prefrontal Cortex
examination
Motor Cortex
Frontal Lobe
Attention Deficit Hyperactivity Disorder
Boys
Gyrus Cinguli
Cortex
geography
Gray Matter

Keywords

  • Childhood
  • Gender
  • Pre-SMA
  • Prefrontal
  • Premotor
  • Segmentation
  • Sex
  • Supplementary Motor Complex (SMC)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Clinical Psychology
  • Neuroscience(all)
  • Language and Linguistics
  • Linguistics and Language

Cite this

Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder. / Mahone, Ernest M; Ranta, Marin E.; Crocetti, Deana; O'Brien, Jessica; Kaufmann, Walter E.; Denckla, Martha Bridge; Mostofsky, Stewart H.

In: Journal of the International Neuropsychological Society, Vol. 17, No. 6, 11.2011, p. 1047-1057.

Research output: Contribution to journalArticle

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