Comprehension deficits elicited by electrical stimulation of Broca's area

Leonard Schäffler, Hans O. Lüders, Dudley S. Dinner, Ronald P Lesser, Gordon J. Chelune

Research output: Contribution to journalArticle

Abstract

We report on three patients with intractable focal seizures arising from the language-dominant left hemisphere. In the work-up prior to surgical treatment, arrays of subdural electrodes were placed over the left temporal lobe and adjacent supra-Sylvian region. Electrical stimulation of the inferior frontal cortex language region ('Broca's area') produced marked interference with language output functions including speech arrest, slowing of oral reading, paraphasia and anomia. At some cortical language sites in this region cortical stimulation also produced language comprehension deficits, particularly in response to more complex auditory verbal instructions and visual semantic material. The severe impairment of comprehension verbal information was in clear contrast with ability to process non-verbal material, which was not affected.

Original languageEnglish (US)
Pages (from-to)695-715
Number of pages21
JournalBrain
Volume116
Issue number3
StatePublished - Jun 1993
Externally publishedYes

Fingerprint

Electric Stimulation
Language
Semantics
Electrodes
Anomia
Aptitude
Hemisphere
Frontal Lobe
Temporal Lobe
Cortex
seizures
electrodes
Electrode
Reading
mouth
Seizures
Adjacent
Interference
Broca Area
Output

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Schäffler, L., Lüders, H. O., Dinner, D. S., Lesser, R. P., & Chelune, G. J. (1993). Comprehension deficits elicited by electrical stimulation of Broca's area. Brain, 116(3), 695-715.

Comprehension deficits elicited by electrical stimulation of Broca's area. / Schäffler, Leonard; Lüders, Hans O.; Dinner, Dudley S.; Lesser, Ronald P; Chelune, Gordon J.

In: Brain, Vol. 116, No. 3, 06.1993, p. 695-715.

Research output: Contribution to journalArticle

Schäffler, L, Lüders, HO, Dinner, DS, Lesser, RP & Chelune, GJ 1993, 'Comprehension deficits elicited by electrical stimulation of Broca's area', Brain, vol. 116, no. 3, pp. 695-715.
Schäffler L, Lüders HO, Dinner DS, Lesser RP, Chelune GJ. Comprehension deficits elicited by electrical stimulation of Broca's area. Brain. 1993 Jun;116(3):695-715.
Schäffler, Leonard ; Lüders, Hans O. ; Dinner, Dudley S. ; Lesser, Ronald P ; Chelune, Gordon J. / Comprehension deficits elicited by electrical stimulation of Broca's area. In: Brain. 1993 ; Vol. 116, No. 3. pp. 695-715.
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