@inproceedings{acd7b635f15e40b0a0707a59b8cc3a08,
title = "Compositional control of pDNA/lPEI nanoparticles using flash nanocomplexation to improve in vivo transfection efficiency and biocompatibility",
abstract = "Linear PEI (lPEI) has proven track record as an effective carrier for the delivery of therapeutic plasmid DNA (pDNA) for disease treatment. However, the lack of a reproducible method to produce pDNA/lPEI nanoparticles with controlled physicochemical characteristics and compositions has long hindered the development of these nanoparticles as a pharmaceutical product. We have employed a turbulent mixing methodology at high Reynolds numbers using the flash nanocomplexation (FNC) technique to achieve efficient and homogenous complexation of pDNA and lPEI. Through precise control of the kinetic conditions for the nanoparticle assembly, uniform nanoparticles with a well-defined composition was developed that presented benefit over both in vivo transfection efficiency and biocompatibility.",
author = "Yizong Hu and Liu, {Heng Wen} and Il Minn and Martin Pomper and Mao, {Hai Quan}",
year = "2019",
month = jan,
day = "1",
language = "English (US)",
series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",
publisher = "Society for Biomaterials",
booktitle = "Society for Biomaterials Annual Meeting and Exposition 2019",
note = "42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence ; Conference date: 03-04-2019 Through 06-04-2019",
}