Composites containing albumin protein or cyanoacrylate adhesives and biodegradable scaffolds: Part II - In vivo wound closure study in a rat model

Karen M. McNally-Heintzelman, Douglas L. Heintzelman, Mark T. Duffy, Jeffrey N. Bloom, Eric C. Soller, Travis M. Gilmour, Grant T. Huffman, Deepak Edward

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Our Scaffold-Enhanced Biological Adhesive (SEBA) system was investigated as an alternative to sutures or adhesives alone for repair of wounds. Two scaffold materials were investigated: (i) a synthetic biodegradable material fabricated from poly(L-lactic-co-glycolic acid); and (ii) a biologic material, small intestinal submucosa, manufactured by Cook BioTech. Two adhesive materials were also investigated: (i) a biologic adhesive composed of 50%(w/v) bovine serum albumin solder and 0.5mg/ml indocyanine green dye mixed in deionized water, and activated with an 808-nm diode laser; and (ii)Ethicon's Dermabond®, a 2-octyl-cyanoacrylate. The tensile strength and time-to-failure of skin incisions repaired in vivo in a rat model were measured at seven days postoperative. Incisions closed by protein solder alone, by Dermabond® alone, or by suture, were also tested for comparison. The tensile strength of repairs formed using the SEBA system were 50% to 65% stronger than repairs formed by suture or either adhesive alone, with significantly less variations within each experimental group (average standard deviations of 15% for SEBA versus 38% for suture and 28% for adhesive alone). In addition, the time-to-failure curves showed a longevity not previously seen with the suture or adhesive alone techniques. The SEBA system acts to keep the dermis in tight apposition during the critical early phase of wound healing when tissue gaps are bridged by scar and granulation tissue. It has the property of being more flexible than either of the adhesives alone and may allow the apposed edges to move in conjunction with each other as a unit for a longer period of time and over a greater range of stresses than adhesives alone. This permits more rapid healing and establishment of integrity since the microgaps between the dermis edges are significantly reduced. By the time the scaffolds are sloughed from the wound site, there is greater strength and healing than that produced by adhesive alone or by wounds following suture removal. This hypothesis is supported by the data of this study, as well as, the acute tensile strength data of Part I of this study.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsK.E. Bartels, L.S. Bass, W.T.W. Riese, K.W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S.J. Madsen, R.S. Malek
Number of pages8
StatePublished - 2004
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States
Duration: Jan 24 2004Jan 27 2004


OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Country/TerritoryUnited States
CitySan Jose, CA


  • Albumin protein solder
  • Biodegradable scaffold
  • Cyanoacrylate
  • Diode laser
  • Indocyanine green dye
  • Suture
  • Tensile strength
  • Time-to-failure
  • Wound closure

ASJC Scopus subject areas

  • Engineering(all)


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