TY - JOUR
T1 - Composite tissue allotransplantation
T2 - Hand transplantation and beyond
AU - Shores, Jaimie T.
AU - Brandacher, Gerald
AU - Schneeberger, Stefan
AU - Gorantla, Vijay S.
AU - AndrewLee, W. P.
PY - 2010/3
Y1 - 2010/3
N2 - Recent advances in transplant immunology are shifting the focus from immunosuppression to immunoregulation, making composite tissue allotransplantation with novel and less potent immunosuppressive regimens a possibility. Hand transplantation has been the most frequently performed human composite tissue allotransplantation, with more than 50 upper extremity-based transplants done worldwide. Further research is needed regarding immunomodulating protocols, and careful oversight and individualized screening procedures will be required as patients seeking improved quality of life through human composite tissue allotransplantation come to accept a certain level of risk in these experimental procedures. Still, composite tissue allotransplantation offers to advance transplant medicine and reconstructive surgery.
AB - Recent advances in transplant immunology are shifting the focus from immunosuppression to immunoregulation, making composite tissue allotransplantation with novel and less potent immunosuppressive regimens a possibility. Hand transplantation has been the most frequently performed human composite tissue allotransplantation, with more than 50 upper extremity-based transplants done worldwide. Further research is needed regarding immunomodulating protocols, and careful oversight and individualized screening procedures will be required as patients seeking improved quality of life through human composite tissue allotransplantation come to accept a certain level of risk in these experimental procedures. Still, composite tissue allotransplantation offers to advance transplant medicine and reconstructive surgery.
UR - http://www.scopus.com/inward/record.url?scp=77949778177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949778177&partnerID=8YFLogxK
U2 - 10.5435/00124635-201003000-00001
DO - 10.5435/00124635-201003000-00001
M3 - Article
C2 - 20190102
AN - SCOPUS:77949778177
SN - 1067-151X
VL - 18
SP - 127
EP - 131
JO - Journal of the American Academy of Orthopaedic Surgeons
JF - Journal of the American Academy of Orthopaedic Surgeons
IS - 3
ER -