Composite tissue allotransplantation: Hand transplantation and beyond

Jaimie T Shores, Gerald Brandacher, Stefan Schneeberger, Vijay S. Gorantla, W P Andrew Lee

Research output: Contribution to journalArticle

Abstract

Recent advances in transplant immunology are shifting the focus from immunosuppression to immunoregulation, making composite tissue allotransplantation with novel and less potent immunosuppressive regimens a possibility. Hand transplantation has been the most frequently performed human composite tissue allotransplantation, with more than 50 upper extremity-based transplants done worldwide. Further research is needed regarding immunomodulating protocols, and careful oversight and individualized screening procedures will be required as patients seeking improved quality of life through human composite tissue allotransplantation come to accept a certain level of risk in these experimental procedures. Still, composite tissue allotransplantation offers to advance transplant medicine and reconstructive surgery.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalThe Journal of the American Academy of Orthopaedic Surgeons
Volume18
Issue number3
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

Vascularized Composite Allotransplantation
Hand Transplantation
Transplants
Reconstructive Surgical Procedures
Immunosuppressive Agents
Allergy and Immunology
Upper Extremity
Immunosuppression
Quality of Life
Medicine
Research

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Composite tissue allotransplantation : Hand transplantation and beyond. / Shores, Jaimie T; Brandacher, Gerald; Schneeberger, Stefan; Gorantla, Vijay S.; Lee, W P Andrew.

In: The Journal of the American Academy of Orthopaedic Surgeons, Vol. 18, No. 3, 03.2010, p. 127-131.

Research output: Contribution to journalArticle

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