Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus: A case report and review of the literature

Steven Sanchez, Houston Holmes, Nora Katabi, Joe Newman, Rana Domiatti-Saad, Marvin Stone, George Netto

Research output: Contribution to journalReview articlepeer-review

Abstract

We report a case of a 65-year-old black man with combined Hodgkin lymphoma and T-cell Iymphoma. The patient presented with diffuse lymphadenopathy, fever, weight loss, and night sweats. Subsequent biopsy of an axillary lymph node revealed a composite lymphoma composed of classic Hodgkin lymphoma and a peripheral T-cell lymphoma. A needle biopsy of the liver also showed involvement by the composite lymphoma. In situ hybridization studies revealed positive Epstein-Barr virus in Reed-Sternberg cells. Development of T-cell lymphoma following chemotherapy for Hodgkin lymphoma has been reported, but synchronous composite occurrence of both lesions is very rare. Furthermore, this is the first report of such occurrence in a black patient. We present a review of the literature and a discussion of the potential pathophysiologic role of Epstein-Barr virus in the early stages of T-cell lymphomagenesis.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number1
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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