Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus

A case report and review of the literature

Steven Sanchez, Houston Holmes, Nora Katabi, Joe Newman, Rana Domiatti-Saad, Marvin Stone, George Netto

Research output: Contribution to journalArticle

Abstract

We report a case of a 65-year-old black man with combined Hodgkin lymphoma and T-cell Iymphoma. The patient presented with diffuse lymphadenopathy, fever, weight loss, and night sweats. Subsequent biopsy of an axillary lymph node revealed a composite lymphoma composed of classic Hodgkin lymphoma and a peripheral T-cell lymphoma. A needle biopsy of the liver also showed involvement by the composite lymphoma. In situ hybridization studies revealed positive Epstein-Barr virus in Reed-Sternberg cells. Development of T-cell lymphoma following chemotherapy for Hodgkin lymphoma has been reported, but synchronous composite occurrence of both lesions is very rare. Furthermore, this is the first report of such occurrence in a black patient. We present a review of the literature and a discussion of the potential pathophysiologic role of Epstein-Barr virus in the early stages of T-cell lymphomagenesis.

Original languageEnglish (US)
Pages (from-to)107-112
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Volume130
Issue number1
StatePublished - Jan 2006

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Peripheral T-Cell Lymphoma
Composite Lymphoma
Human Herpesvirus 4
Hodgkin Disease
Lymphocytes
Reed-Sternberg Cells
T-Lymphocytes
Sweat
T-Cell Lymphoma
Needle Biopsy
In Situ Hybridization
Weight Loss
Fever
Lymph Nodes
Biopsy
Drug Therapy
Liver

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus : A case report and review of the literature. / Sanchez, Steven; Holmes, Houston; Katabi, Nora; Newman, Joe; Domiatti-Saad, Rana; Stone, Marvin; Netto, George.

In: Archives of Pathology and Laboratory Medicine, Vol. 130, No. 1, 01.2006, p. 107-112.

Research output: Contribution to journalArticle

Sanchez, Steven ; Holmes, Houston ; Katabi, Nora ; Newman, Joe ; Domiatti-Saad, Rana ; Stone, Marvin ; Netto, George. / Composite lymphocyte-rich Hodgkin lymphoma and peripheral T-cell lymphoma associated with Epstein-Barr virus : A case report and review of the literature. In: Archives of Pathology and Laboratory Medicine. 2006 ; Vol. 130, No. 1. pp. 107-112.
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