Abstract
Aims Microcarcinoids refer to microscopic nests of monotonous cells with endocrine and squamoid features. Their peculiar morphology can appear infiltrative with a desmoplastic-like background, raising concerns for an infiltrating adenocarcinoma. To further characterise microcarcinoids, we undertook a prospective clinicopathological study. Methods 11 specimens originating from five men and six women (average age=58.9 years) were prospectively collected from December 2004 to December 2011. Results Microcarcinoids were most commonly identified in high-risk adenomas (size =10 mm (n=10), villous components (n=8) and/or high-grade dysplasia (n=4)). All polyps had mucosal prolapse and four displayed background fibrosis reminiscent of desmoplasia. The microcarcinoid component was most often multifocal (n=7) within the individual polyp and extended over an average length of 3.9 mm. The individual microcarcinoid cells were cuboidal with abundant eosinophilic cytoplasm. All cases had monotonous nuclei which lacked pleomorphism, hyperchromasia and mitotic activity. All available microcarcinoids were β-catenin and synaptophysin reactive and non-reactive for chromogranin and p53 with a negligible Ki-67 proliferation index (
| Original language | English (US) |
|---|---|
| Pages (from-to) | 302-306 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2013 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Composite intestinal adenoma-microcarcinoid clues to diagnosing an under-recognised mimic of invasive adenocarcinoma. / Salaria, Safia N.; Alfa, Amer K Abu; Alsaigh, Nada Y.; Montgomery, Elizabeth A; Arnold, Christina A.
In: Journal of Clinical Pathology, Vol. 66, No. 4, 04.2013, p. 302-306.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Composite intestinal adenoma-microcarcinoid clues to diagnosing an under-recognised mimic of invasive adenocarcinoma
AU - Salaria, Safia N.
AU - Alfa, Amer K Abu
AU - Alsaigh, Nada Y.
AU - Montgomery, Elizabeth A
AU - Arnold, Christina A.
PY - 2013/4
Y1 - 2013/4
N2 - Aims Microcarcinoids refer to microscopic nests of monotonous cells with endocrine and squamoid features. Their peculiar morphology can appear infiltrative with a desmoplastic-like background, raising concerns for an infiltrating adenocarcinoma. To further characterise microcarcinoids, we undertook a prospective clinicopathological study. Methods 11 specimens originating from five men and six women (average age=58.9 years) were prospectively collected from December 2004 to December 2011. Results Microcarcinoids were most commonly identified in high-risk adenomas (size =10 mm (n=10), villous components (n=8) and/or high-grade dysplasia (n=4)). All polyps had mucosal prolapse and four displayed background fibrosis reminiscent of desmoplasia. The microcarcinoid component was most often multifocal (n=7) within the individual polyp and extended over an average length of 3.9 mm. The individual microcarcinoid cells were cuboidal with abundant eosinophilic cytoplasm. All cases had monotonous nuclei which lacked pleomorphism, hyperchromasia and mitotic activity. All available microcarcinoids were β-catenin and synaptophysin reactive and non-reactive for chromogranin and p53 with a negligible Ki-67 proliferation index (
AB - Aims Microcarcinoids refer to microscopic nests of monotonous cells with endocrine and squamoid features. Their peculiar morphology can appear infiltrative with a desmoplastic-like background, raising concerns for an infiltrating adenocarcinoma. To further characterise microcarcinoids, we undertook a prospective clinicopathological study. Methods 11 specimens originating from five men and six women (average age=58.9 years) were prospectively collected from December 2004 to December 2011. Results Microcarcinoids were most commonly identified in high-risk adenomas (size =10 mm (n=10), villous components (n=8) and/or high-grade dysplasia (n=4)). All polyps had mucosal prolapse and four displayed background fibrosis reminiscent of desmoplasia. The microcarcinoid component was most often multifocal (n=7) within the individual polyp and extended over an average length of 3.9 mm. The individual microcarcinoid cells were cuboidal with abundant eosinophilic cytoplasm. All cases had monotonous nuclei which lacked pleomorphism, hyperchromasia and mitotic activity. All available microcarcinoids were β-catenin and synaptophysin reactive and non-reactive for chromogranin and p53 with a negligible Ki-67 proliferation index (
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UR - http://www.scopus.com/inward/citedby.url?scp=84875216923&partnerID=8YFLogxK
U2 - 10.1136/jclinpath-2012-201314
DO - 10.1136/jclinpath-2012-201314
M3 - Article
C2 - 23393204
AN - SCOPUS:84875216923
VL - 66
SP - 302
EP - 306
JO - Journal of Clinical Pathology
JF - Journal of Clinical Pathology
SN - 0021-9746
IS - 4
ER -