Composite intestinal adenoma-microcarcinoid clues to diagnosing an under-recognised mimic of invasive adenocarcinoma

Safia N. Salaria, Amer K Abu Alfa, Nada Y. Alsaigh, Elizabeth A Montgomery, Christina A. Arnold

Research output: Contribution to journalArticle

Abstract

Aims Microcarcinoids refer to microscopic nests of monotonous cells with endocrine and squamoid features. Their peculiar morphology can appear infiltrative with a desmoplastic-like background, raising concerns for an infiltrating adenocarcinoma. To further characterise microcarcinoids, we undertook a prospective clinicopathological study. Methods 11 specimens originating from five men and six women (average age=58.9 years) were prospectively collected from December 2004 to December 2011. Results Microcarcinoids were most commonly identified in high-risk adenomas (size =10 mm (n=10), villous components (n=8) and/or high-grade dysplasia (n=4)). All polyps had mucosal prolapse and four displayed background fibrosis reminiscent of desmoplasia. The microcarcinoid component was most often multifocal (n=7) within the individual polyp and extended over an average length of 3.9 mm. The individual microcarcinoid cells were cuboidal with abundant eosinophilic cytoplasm. All cases had monotonous nuclei which lacked pleomorphism, hyperchromasia and mitotic activity. All available microcarcinoids were β-catenin and synaptophysin reactive and non-reactive for chromogranin and p53 with a negligible Ki-67 proliferation index (

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalJournal of Clinical Pathology
Volume66
Issue number4
DOIs
StatePublished - Apr 2013

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Polyps
Adenoma
Adenocarcinoma
Chromogranins
Catenins
Synaptophysin
Endocrine Cells
Prolapse
Cytoplasm
Fibrosis
Prospective Studies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Composite intestinal adenoma-microcarcinoid clues to diagnosing an under-recognised mimic of invasive adenocarcinoma. / Salaria, Safia N.; Alfa, Amer K Abu; Alsaigh, Nada Y.; Montgomery, Elizabeth A; Arnold, Christina A.

In: Journal of Clinical Pathology, Vol. 66, No. 4, 04.2013, p. 302-306.

Research output: Contribution to journalArticle

Salaria, Safia N. ; Alfa, Amer K Abu ; Alsaigh, Nada Y. ; Montgomery, Elizabeth A ; Arnold, Christina A. / Composite intestinal adenoma-microcarcinoid clues to diagnosing an under-recognised mimic of invasive adenocarcinoma. In: Journal of Clinical Pathology. 2013 ; Vol. 66, No. 4. pp. 302-306.
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AU - Arnold, Christina A.

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