Complications of AlphaCor keratoprosthesis: A clinicopathologic report

Kakarla V. Chalam, Amit Chokshi, Swati Agarwal, Deepak P. Edward

Research output: Contribution to journalArticle

Abstract

PURPOSE: To describe the clinical and histopathologic features of intractable secondary glaucoma induced by AlphaCor keratoprosthesis. METHODS: An elderly woman with pseudoexfoliation glaucoma and pseudophakic bullous keratopathy in the right eye had graft failures after penetrating keratoplasty. Her best-corrected visual acuity at presentation was counting fingers in the right eye and 20/30 in the left eye. Examination showed severe corneal neovascularization. Chirila keratoprosthesis type II was implanted in 2 stages. Ten months later, the patient developed dense retrocorneal membrane, 360° occlusion of angles, intractable glaucoma, no light perception, and nasal stromal melting associated with partial extrusion of the keratoprosthesis. RESULTS: Histopathology revealed invasion of the porous material of the keratoprosthesis by reactive fibroblasts and multinucleated foreign-body giant cells. In the area of dehiscence, we noted thinning and lysis of the collagen fibers, infiltration of lymphocytes, and plasma cells with a sheet of fibroinflammatory tissue extending into the anterior chamber. CONCLUSIONS: Corneal stromal melting and retrocorneal prosthetic membrane formation after AlphaCor keratoprosthesis implantation led to intractable glaucoma and extrusion of the implant.

Original languageEnglish (US)
Pages (from-to)1258-1260
Number of pages3
JournalCornea
Volume26
Issue number10
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Glaucoma
Freezing
Foreign Body Giant Cells
Corneal Neovascularization
Penetrating Keratoplasty
Membranes
Anterior Chamber
Plasma Cells
Nose
Fingers
Visual Acuity
Collagen
Fibroblasts
Lymphocytes
Transplants
Light

Keywords

  • AlphaCor keratoprosthesis
  • Complication
  • Graft failure
  • Histopathology
  • Penetrating keratoplasty

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chalam, K. V., Chokshi, A., Agarwal, S., & Edward, D. P. (2007). Complications of AlphaCor keratoprosthesis: A clinicopathologic report. Cornea, 26(10), 1258-1260. https://doi.org/10.1097/ICO.0b013e31813e0bd8

Complications of AlphaCor keratoprosthesis : A clinicopathologic report. / Chalam, Kakarla V.; Chokshi, Amit; Agarwal, Swati; Edward, Deepak P.

In: Cornea, Vol. 26, No. 10, 12.2007, p. 1258-1260.

Research output: Contribution to journalArticle

Chalam, KV, Chokshi, A, Agarwal, S & Edward, DP 2007, 'Complications of AlphaCor keratoprosthesis: A clinicopathologic report', Cornea, vol. 26, no. 10, pp. 1258-1260. https://doi.org/10.1097/ICO.0b013e31813e0bd8
Chalam, Kakarla V. ; Chokshi, Amit ; Agarwal, Swati ; Edward, Deepak P. / Complications of AlphaCor keratoprosthesis : A clinicopathologic report. In: Cornea. 2007 ; Vol. 26, No. 10. pp. 1258-1260.
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