Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement

John V. Conte, James Hermiller, Jon R. Resar, G. Michael Deeb, Thomas G. Gleason, David H. Adams, Jeffrey J. Popma, Steven J. Yakubov, Daniel Watson, Jia Guo, George L. Zorn, Michael J. Reardon

Research output: Research - peer-reviewArticle

Abstract

Procedural complications following transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) are usually reported as retrospective analyses. We report the first comparison of complications following SAVR or self-expanding TAVR from a prospectively randomized study of high-risk SAVR patients. Three hundred ninety-five TAVR and 402 SAVR patients were prospectively enrolled and randomized 1:1 to TAVR with a CoreValve bioprosthesis or a surgical bioprosthetic valve. The rates of major procedural and vascular complications occurring (periprocedurally (0-3 days) and early (4-30 days)) were compared for TAVR vs SAVR patients. All-cause mortality, stroke, myocardial infarction, and major infection were similar in both periods post procedure. Within 0-3 days, the major vascular complication rate was significantly higher with TAVR (P = 0.003). Life-threatening or disabling bleeding (P < 0.001), encephalopathy (P = 0.02), atrial fibrillation (P < 0.001), and acute kidney injury (P < 0.001) were significantly higher with SAVR. Non-iliofemoral TAVR approaches had a higher incidence of major or life-threatening or disabling bleeding at 0-3days (P < 0.05). Procedural complications unique to TAVR included coronary occlusion 0.5% (2) and TAVR pop outs 2.8% (11) with no valve embolizations. Pop outs were similar between iliofemoral 2.8% (9/324) and non-iliofemoral approaches 3.0% (2/66). Procedural complications unique to SAVR included aortic dissection 0.8% (3/357) and injury to other heart structures 2.0% (7/357). The procedural complication profiles of TAVR and SAVR are unique. Intraoperative deaths were seen in TAVR only. Mortality at 3 and 30 days was similar. The higher incidence of some complications likely reflects the greater invasiveness of SAVR in this aged high-risk population.

LanguageEnglish (US)
JournalSeminars in Thoracic and Cardiovascular Surgery
DOIs
StateAccepted/In press - 2017

Fingerprint

Aortic Valve
Surgical Instruments
Transcatheter Aortic Valve Replacement
Blood Vessels
Hemorrhage
Mortality
Incidence
Bioprosthesis
Coronary Occlusion
Brain Diseases
Acute Kidney Injury
Atrial Fibrillation
Dissection
Stroke
Myocardial Infarction
Wounds and Injuries
Infection
Population

Keywords

  • Acute kidney injury
  • Bleeding
  • Complications
  • SAVR
  • TAVR

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement. / Conte, John V.; Hermiller, James; Resar, Jon R.; Deeb, G. Michael; Gleason, Thomas G.; Adams, David H.; Popma, Jeffrey J.; Yakubov, Steven J.; Watson, Daniel; Guo, Jia; Zorn, George L.; Reardon, Michael J.

In: Seminars in Thoracic and Cardiovascular Surgery, 2017.

Research output: Research - peer-reviewArticle

Conte, JV, Hermiller, J, Resar, JR, Deeb, GM, Gleason, TG, Adams, DH, Popma, JJ, Yakubov, SJ, Watson, D, Guo, J, Zorn, GL & Reardon, MJ 2017, 'Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement' Seminars in Thoracic and Cardiovascular Surgery. DOI: 10.1053/j.semtcvs.2017.06.001
Conte, John V. ; Hermiller, James ; Resar, Jon R. ; Deeb, G. Michael ; Gleason, Thomas G. ; Adams, David H. ; Popma, Jeffrey J. ; Yakubov, Steven J. ; Watson, Daniel ; Guo, Jia ; Zorn, George L. ; Reardon, Michael J./ Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement. In: Seminars in Thoracic and Cardiovascular Surgery. 2017
@article{208c9168a15e4d859509a2b6aa7c750b,
title = "Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement",
abstract = "Procedural complications following transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) are usually reported as retrospective analyses. We report the first comparison of complications following SAVR or self-expanding TAVR from a prospectively randomized study of high-risk SAVR patients. Three hundred ninety-five TAVR and 402 SAVR patients were prospectively enrolled and randomized 1:1 to TAVR with a CoreValve bioprosthesis or a surgical bioprosthetic valve. The rates of major procedural and vascular complications occurring (periprocedurally (0-3 days) and early (4-30 days)) were compared for TAVR vs SAVR patients. All-cause mortality, stroke, myocardial infarction, and major infection were similar in both periods post procedure. Within 0-3 days, the major vascular complication rate was significantly higher with TAVR (P = 0.003). Life-threatening or disabling bleeding (P < 0.001), encephalopathy (P = 0.02), atrial fibrillation (P < 0.001), and acute kidney injury (P < 0.001) were significantly higher with SAVR. Non-iliofemoral TAVR approaches had a higher incidence of major or life-threatening or disabling bleeding at 0-3days (P < 0.05). Procedural complications unique to TAVR included coronary occlusion 0.5% (2) and TAVR pop outs 2.8% (11) with no valve embolizations. Pop outs were similar between iliofemoral 2.8% (9/324) and non-iliofemoral approaches 3.0% (2/66). Procedural complications unique to SAVR included aortic dissection 0.8% (3/357) and injury to other heart structures 2.0% (7/357). The procedural complication profiles of TAVR and SAVR are unique. Intraoperative deaths were seen in TAVR only. Mortality at 3 and 30 days was similar. The higher incidence of some complications likely reflects the greater invasiveness of SAVR in this aged high-risk population.",
keywords = "Acute kidney injury, Bleeding, Complications, SAVR, TAVR",
author = "Conte, {John V.} and James Hermiller and Resar, {Jon R.} and Deeb, {G. Michael} and Gleason, {Thomas G.} and Adams, {David H.} and Popma, {Jeffrey J.} and Yakubov, {Steven J.} and Daniel Watson and Jia Guo and Zorn, {George L.} and Reardon, {Michael J.}",
year = "2017",
doi = "10.1053/j.semtcvs.2017.06.001",
journal = "Seminars in Thoracic and Cardiovascular Surgery",
issn = "1043-0679",
publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Complications After Self-expanding Transcatheter or Surgical Aortic Valve Replacement

AU - Conte,John V.

AU - Hermiller,James

AU - Resar,Jon R.

AU - Deeb,G. Michael

AU - Gleason,Thomas G.

AU - Adams,David H.

AU - Popma,Jeffrey J.

AU - Yakubov,Steven J.

AU - Watson,Daniel

AU - Guo,Jia

AU - Zorn,George L.

AU - Reardon,Michael J.

PY - 2017

Y1 - 2017

N2 - Procedural complications following transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) are usually reported as retrospective analyses. We report the first comparison of complications following SAVR or self-expanding TAVR from a prospectively randomized study of high-risk SAVR patients. Three hundred ninety-five TAVR and 402 SAVR patients were prospectively enrolled and randomized 1:1 to TAVR with a CoreValve bioprosthesis or a surgical bioprosthetic valve. The rates of major procedural and vascular complications occurring (periprocedurally (0-3 days) and early (4-30 days)) were compared for TAVR vs SAVR patients. All-cause mortality, stroke, myocardial infarction, and major infection were similar in both periods post procedure. Within 0-3 days, the major vascular complication rate was significantly higher with TAVR (P = 0.003). Life-threatening or disabling bleeding (P < 0.001), encephalopathy (P = 0.02), atrial fibrillation (P < 0.001), and acute kidney injury (P < 0.001) were significantly higher with SAVR. Non-iliofemoral TAVR approaches had a higher incidence of major or life-threatening or disabling bleeding at 0-3days (P < 0.05). Procedural complications unique to TAVR included coronary occlusion 0.5% (2) and TAVR pop outs 2.8% (11) with no valve embolizations. Pop outs were similar between iliofemoral 2.8% (9/324) and non-iliofemoral approaches 3.0% (2/66). Procedural complications unique to SAVR included aortic dissection 0.8% (3/357) and injury to other heart structures 2.0% (7/357). The procedural complication profiles of TAVR and SAVR are unique. Intraoperative deaths were seen in TAVR only. Mortality at 3 and 30 days was similar. The higher incidence of some complications likely reflects the greater invasiveness of SAVR in this aged high-risk population.

AB - Procedural complications following transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) are usually reported as retrospective analyses. We report the first comparison of complications following SAVR or self-expanding TAVR from a prospectively randomized study of high-risk SAVR patients. Three hundred ninety-five TAVR and 402 SAVR patients were prospectively enrolled and randomized 1:1 to TAVR with a CoreValve bioprosthesis or a surgical bioprosthetic valve. The rates of major procedural and vascular complications occurring (periprocedurally (0-3 days) and early (4-30 days)) were compared for TAVR vs SAVR patients. All-cause mortality, stroke, myocardial infarction, and major infection were similar in both periods post procedure. Within 0-3 days, the major vascular complication rate was significantly higher with TAVR (P = 0.003). Life-threatening or disabling bleeding (P < 0.001), encephalopathy (P = 0.02), atrial fibrillation (P < 0.001), and acute kidney injury (P < 0.001) were significantly higher with SAVR. Non-iliofemoral TAVR approaches had a higher incidence of major or life-threatening or disabling bleeding at 0-3days (P < 0.05). Procedural complications unique to TAVR included coronary occlusion 0.5% (2) and TAVR pop outs 2.8% (11) with no valve embolizations. Pop outs were similar between iliofemoral 2.8% (9/324) and non-iliofemoral approaches 3.0% (2/66). Procedural complications unique to SAVR included aortic dissection 0.8% (3/357) and injury to other heart structures 2.0% (7/357). The procedural complication profiles of TAVR and SAVR are unique. Intraoperative deaths were seen in TAVR only. Mortality at 3 and 30 days was similar. The higher incidence of some complications likely reflects the greater invasiveness of SAVR in this aged high-risk population.

KW - Acute kidney injury

KW - Bleeding

KW - Complications

KW - SAVR

KW - TAVR

UR - http://www.scopus.com/inward/record.url?scp=85027111471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027111471&partnerID=8YFLogxK

U2 - 10.1053/j.semtcvs.2017.06.001

DO - 10.1053/j.semtcvs.2017.06.001

M3 - Article

JO - Seminars in Thoracic and Cardiovascular Surgery

T2 - Seminars in Thoracic and Cardiovascular Surgery

JF - Seminars in Thoracic and Cardiovascular Surgery

SN - 1043-0679

ER -