Complexities in cardiovascular rhythmicity: Perspectives on circadian normality, ageing and disease

Oliver Monfredi, Edward G. Lakatta

Research output: Contribution to journalArticlepeer-review


Biological rhythms exist in organisms at all levels of complexity, in most organs and at myriad time scales. Our own biological rhythms are driven by energy emitted by the sun, interacting via our retinas with brain stem centres, which then send out complex messages designed to synchronize the behaviour of peripheral non-light sensing organs, to ensure optimal physiological responsiveness and performance of the organism based on the time of day. Peripheral organs themselves have autonomous rhythmic behaviours that can act independently from central nervous system control but is entrainable. Dysregulation of biological rhythms either through environment or disease has far-reaching consequences on health that we are only now beginning to appreciate. In this review, we focus on cardiovascular rhythms in health, with ageing and under disease conditions.

Original languageEnglish (US)
Pages (from-to)1576-1595
Number of pages20
JournalCardiovascular research
Issue number11
StatePublished - Sep 1 2019
Externally publishedYes


  • Cardiovascular
  • Circadian rhythm
  • Heart rate variability
  • Sinus node

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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