Abstract
Biological rhythms exist in organisms at all levels of complexity, in most organs and at myriad time scales. Our own biological rhythms are driven by energy emitted by the sun, interacting via our retinas with brain stem centres, which then send out complex messages designed to synchronize the behaviour of peripheral non-light sensing organs, to ensure optimal physiological responsiveness and performance of the organism based on the time of day. Peripheral organs themselves have autonomous rhythmic behaviours that can act independently from central nervous system control but is entrainable. Dysregulation of biological rhythms either through environment or disease has far-reaching consequences on health that we are only now beginning to appreciate. In this review, we focus on cardiovascular rhythms in health, with ageing and under disease conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1576-1595 |
| Number of pages | 20 |
| Journal | Cardiovascular research |
| Volume | 115 |
| Issue number | 11 |
| DOIs | |
| State | Published - Sep 1 2019 |
| Externally published | Yes |
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Keywords
- Cardiovascular
- Circadian rhythm
- Heart rate variability
- Sinus node
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
Cite this
Complexities in cardiovascular rhythmicity : perspectives on circadian normality, ageing and disease. / Monfredi, Oliver; Lakatta, Edward G.
In: Cardiovascular research, Vol. 115, No. 11, 01.09.2019, p. 1576-1595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Complexities in cardiovascular rhythmicity
T2 - perspectives on circadian normality, ageing and disease
AU - Monfredi, Oliver
AU - Lakatta, Edward G.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Biological rhythms exist in organisms at all levels of complexity, in most organs and at myriad time scales. Our own biological rhythms are driven by energy emitted by the sun, interacting via our retinas with brain stem centres, which then send out complex messages designed to synchronize the behaviour of peripheral non-light sensing organs, to ensure optimal physiological responsiveness and performance of the organism based on the time of day. Peripheral organs themselves have autonomous rhythmic behaviours that can act independently from central nervous system control but is entrainable. Dysregulation of biological rhythms either through environment or disease has far-reaching consequences on health that we are only now beginning to appreciate. In this review, we focus on cardiovascular rhythms in health, with ageing and under disease conditions.
AB - Biological rhythms exist in organisms at all levels of complexity, in most organs and at myriad time scales. Our own biological rhythms are driven by energy emitted by the sun, interacting via our retinas with brain stem centres, which then send out complex messages designed to synchronize the behaviour of peripheral non-light sensing organs, to ensure optimal physiological responsiveness and performance of the organism based on the time of day. Peripheral organs themselves have autonomous rhythmic behaviours that can act independently from central nervous system control but is entrainable. Dysregulation of biological rhythms either through environment or disease has far-reaching consequences on health that we are only now beginning to appreciate. In this review, we focus on cardiovascular rhythms in health, with ageing and under disease conditions.
KW - Cardiovascular
KW - Circadian rhythm
KW - Heart rate variability
KW - Sinus node
UR - http://www.scopus.com/inward/record.url?scp=85071707717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071707717&partnerID=8YFLogxK
U2 - 10.1093/cvr/cvz112
DO - 10.1093/cvr/cvz112
M3 - Article
C2 - 31150049
AN - SCOPUS:85071707717
VL - 115
SP - 1576
EP - 1595
JO - Cardiovascular Research
JF - Cardiovascular Research
SN - 0008-6363
IS - 11
ER -