Complex segregation analysis of nasopharyngeal carcinoma in Guangdong, China: Evidence for a multifactorial mode of inheritance (complex segregation analysis of NPC in China)

Wei Hua Jia, Andrew Collins, Yi Xin Zeng, Bing Jian Feng, Xing Juan Yu, Li Xi Huang, Qi Sheng Feng, Ping Huang, Ming Hong Yao, Yin Yao Shugart

Research output: Contribution to journalArticlepeer-review

Abstract

The striking geographical and ethnic distribution of nasopharyngeal carcinoma (NPC) suggests the involvement of genetic and environmental factors in NPC development. The purpose of this study is to investigate the fit of single gene, polygenic and multifactorial models to the observed pattern of transmission of NPC in a hospital-based family history study conducted by the Cancer Center of Sun Yat-Sen University (CCSYU) in Guangzhou, China. Complex segregation analysis of a total of 1903 Cantonese pedigrees ascertained at CCSYU was conducted using a unified mixed model after the pedigrees were partitioned into 3737 nuclear families. The mixed model assumes that a phenotype is influenced by the additive and independent effect of a major gene, together with multifactorial components (genetic and environmental) and a random environmental effect. The current results do not provide evidence for a major gene and the observed data are best explained by a multifactorial mode of inheritance for NPC.

Original languageEnglish (US)
Pages (from-to)248-252
Number of pages5
JournalEuropean Journal of Human Genetics
Volume13
Issue number2
DOIs
StatePublished - Feb 2005

Keywords

  • Complex segregation analysis
  • Mode of inheritance
  • Multifactorial model
  • Nasopharyngeal carcinoma (NPC)

ASJC Scopus subject areas

  • Genetics(clinical)

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