TY - JOUR
T1 - Complex dynamics in coupled cardiac pacemaker cells
AU - Cai, Dongming
AU - Lai, Ying Cheng
AU - Winslow, Raimond L.
PY - 1993
Y1 - 1993
N2 - We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-artial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.
AB - We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-artial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.
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U2 - 10.1103/PhysRevLett.71.2501
DO - 10.1103/PhysRevLett.71.2501
M3 - Article
AN - SCOPUS:0001597222
SN - 0031-9007
VL - 71
SP - 2501
EP - 2504
JO - Physical Review Letters
JF - Physical Review Letters
IS - 15
ER -