Complex character analysis of heart rate variability following brain asphyxia

Yuanyuan Cai; Yihong Qiu; Lan Wei; Wei Zhang; Sijun Hu; Peter R. Smith; Vincent P. Crabtree; Shanbao Tong; Nitish V. Thakor; Yisheng Zhu

doi:10.1016/j.medengphy.2005.05.002

Complex character analysis of heart rate variability following brain asphyxia

Yuanyuan Cai, Yihong Qiu, Lan Wei, Wei Zhang, Sijun Hu, Peter R. Smith, Vincent P. Crabtree, Shanbao Tong, Nitish V. Thakor, Yisheng Zhu

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In the present study Renyi entropy and L-Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L-Z complexity of the R-R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.

Original language	English (US)
Pages (from-to)	297-303
Number of pages	7
Journal	Medical Engineering and Physics
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.medengphy.2005.05.002
State	Published - May 2006

Keywords

Brain asphyxia
Heart rate variability
L-Z complexity
Renyi entropy

ASJC Scopus subject areas

Biophysics
Biomedical Engineering

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10.1016/j.medengphy.2005.05.002

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title = "Complex character analysis of heart rate variability following brain asphyxia",

abstract = "In the present study Renyi entropy and L-Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L-Z complexity of the R-R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.",

keywords = "Brain asphyxia, Heart rate variability, L-Z complexity, Renyi entropy",

author = "Yuanyuan Cai and Yihong Qiu and Lan Wei and Wei Zhang and Sijun Hu and Smith, {Peter R.} and Crabtree, {Vincent P.} and Shanbao Tong and Thakor, {Nitish V.} and Yisheng Zhu",

note = "Funding Information: This research is supported by the grant 60272326 of National Natural Science Foundation of China and the 973 grant 2005CB7243 of National Natural Science Foundation of China. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = may,

doi = "10.1016/j.medengphy.2005.05.002",

language = "English (US)",

volume = "28",

pages = "297--303",

journal = "Medical Engineering and Physics",

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T1 - Complex character analysis of heart rate variability following brain asphyxia

AU - Cai, Yuanyuan

AU - Qiu, Yihong

AU - Wei, Lan

AU - Zhang, Wei

AU - Hu, Sijun

AU - Smith, Peter R.

AU - Crabtree, Vincent P.

AU - Tong, Shanbao

AU - Thakor, Nitish V.

AU - Zhu, Yisheng

N1 - Funding Information: This research is supported by the grant 60272326 of National Natural Science Foundation of China and the 973 grant 2005CB7243 of National Natural Science Foundation of China. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/5

Y1 - 2006/5

N2 - In the present study Renyi entropy and L-Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L-Z complexity of the R-R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.

AB - In the present study Renyi entropy and L-Z complexity were used to characterize heart rate variability (HRV) of rats that were suffered from brain asphyxia and ischemia. Two groups of rats were studied: (a) rats (n = 5) injected with NAALADase inhibitor, 2-PMPA, which has been proven neuroprotective in asphyxia injury and (b) control subjects (n = 5) without medication. Renyi entropy and L-Z complexity of the R-R intervals (RRI) at different experiment stages were investigated in the two groups. The results show that both measures indicate less injury and better recovery in the drug injection group. The dynamic change of 90 min RRI signal after the asphyxia was investigated. The sudden reduction of the two parameters shows their sensitivity to the asphyxia insult.

KW - Brain asphyxia

KW - Heart rate variability

KW - L-Z complexity

KW - Renyi entropy

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ER -

Complex character analysis of heart rate variability following brain asphyxia

Abstract

Keywords

ASJC Scopus subject areas

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